Nonclinical Metabolite Identification
- Soft spot identification
- In vitro cross species comparison
- Preclinical AME/ADME
Profiling and identifying metabolites are key steps in supporting drug discovery and development of novel compounds. Metabolite identification (MetID) studies help you to understand the clearance mechanisms, parse the presence of potential active or reactive metabolites and observe the disproportionate or unique metabolites in your compound to better understand your molecule's biotransformation capabilities.
Understanding the biotransformation of your compounds during lead optimization enhances your lead candidate’s properties and enables you to make informed decisions early, preventing costly development delays.
Metabolite identification studies occur throughout the drug or device development continuum. Data generated from these studies supports the following regulatory guidelines for DMPK studies: