Comprehensive Leukocyte Quantitation
The CompLeukocyte™ package provides our portfolio’s most comprehensive profile capability by enabling the analysis of 11 immune cell subsets. The CompLeukocyte™ package includes 2 immunophenotyping panels and 1 quantitation panel to enable absolute cell counts within tissues.
In the data shown, CT26 tumor-bearing mice were treated with an anti-mCTLA-4 checkpoint inhibitor or an isotype control. Tumors were harvested on day 18 to measure:
Absolute counts of tumor-infiltrating cells
CD69* and PD-1 on tumor-derived CD8+ T cells
Ki-67 median fluorescence intensity (MFI) to examine CD8+ T cell proliferation
*CD69 can be substituted for other markers including LAG3, ICOS, or CTLA-4.