Adoptive Cell Therapies (ACT) & CAR T Cell

With over 80 unique hematological malignancy cell lines, such as the CD19+ Raji-Luc lymphoma model, the MV-411-Luc leukemia model, and the MM.1S-Luc multiple myeloma model, we lead the industry with market-relevant models for your studies. We also have an ever-expanding list of solid tumor models validated in NSG mice to support the field’s drive toward approval of an adoptive cell therapy (ACT) in a solid tumor indication.

Discover an unparalleled breadth of experience in the use of mouse tumor models to evaluate adoptive cell therapies (ACTs). With a broad range of disseminated and subcutaneous tumor models characterized in NSG mice, and a scientific team that knows how to apply them, we can guide selection of the right tumor model for your CAR T cell or other ACT study.

Tumor Models Characterized in NSG Mice

Models (Currently Available)
Model Histotype
22Rv1 Prostate carcinoma
H-1299 Non-small cell lung carcinoma
Hep 3B2.1-7 Hepatocellular carcinoma
KG-1-Luc-mCh-Puro Myeloid leukemia
MM1.S (pMMP-Luc-Neo) Plasma cell myeloma
MOLM-13 Plasma cell myeloma
MV4-11-FUW-Luc-mCh-Puro Acute monocytic leukemia (AML)
NALM6-Luc-mCh-Puro Lymphoblastic leukemia
NCI-H929-Luc-mCh-Puro Plasma cell myeloma
PC-3 Prostate carcinoma
Raji-Luc Lymphoma
RPMI-8226 Plasma cell myeloma
SK-MEL-28 Melanoma
SK-OV-3-Luc-D3  &  SK-OV-3 Ovarian adenocarcinoma
SNU-5 Gastric carcinoma
U-251-Luc-mCh-Puro Glioblastoma
Models (In Progress)
Model Histotype
A549 Non small cell lung carcinoma
BT-20 Mammary ductal carcinoma
BT-474 Mammary ductal carcinoma
BxPC-3 Pancreatic adenocarcinoma
H-1299 Non-small cell lung carcinoma
Jurkat Lymphoblastic leukemia
MDA-MB-231-Luc-D3H2LN Mammary carcinoma
NCI-H1703 Squamous cell lung carcinoma
NCI-H1975 Lung adenocarcinoma
SK-BR-3 Mammary adenocarcinoma

Tumor Models by Histotype, Targeted with Adoptive Cell Therapy

Hematological Malignancies:

Acute Myeloid Leukemia
Leukemia [AML]
EOL-1
Kasumi-3
Kasumi-3-Luc-mCh-Puro
KG-1-Luc-mCh-Puro
MOLM-13
MV-4-11
NOMO-1
Human
C1498
Mouse
B-cell Malignancies
Leukemia [B-ALL]
NALM6
NALM6-Luc-MCh-Puro
Reh
RS4;11
Human
Lymphoma [B-Cell]
DB
DB/M2
Human
Mouse
Lymphoma [B-NHL]
Farage
GRANTA-519
Human
Lymphoma [Burkitt’s]
B-JAB
Daudi
NAMALWA
Raji
Ramos-Luc
Human
Lymphoma [DLBCL]
OCI-Ly1 LN
OCI-Ly19-Luc-Neo
OCI-Ly3-Luc-mCh-Puro
OCI-Ly7-Luc-mCh-Puro (rescued)
OCI-Ly7-Luc-Neo
Pfeiffer
SU-DHL-10-LN-High
SU-DHL-16
SU-DHL-4-Luc-mCh-Puro
SU-DHL-8
TMD8
Toledo-Luc-Neo
WSU-DLCL2
Human
Multiple Myeloma
Myeloma
JJN-3-Luc
NCI-H929
OPM-2
RPMI 8226
U266B1
Human
J558
Mouse

Solid Tumors:

Glioblastoma Multiforme
Brain
BT142
DBTRG (tumor)
DBTRG-05MG
Gli36-DsRed-R-Luc (rescued)
LN-18
LN-229
M059K
SF-295
SF-539
SF-767
SNB-19
U-87 MG
U251
Human
GL261
Mouse
Hepatocellular Carcinoma
Liver
Hep 3B2.1-7
Hep G2
Human
BNL 1ME A.7R.1
BNL 1ME A.7R.1-Luc-mCh-Puro
Hep55.1c
Hepa 1-6-Luc-mCh-Puro
Mouse
Lung
Lung
LL/2-Luc-M38
Mouse
Lung [Adenosquamous]
NCI-H596
Human
Lung [Anaplastic Carcinoma]
Calu-6
Human
Lung [Bronchioalveolar]
NCI-H322M
Human
Lung [NSCLC]
A549-Luc-C8
Calu-1
Calu-3
HCC827
HCC827-Luc-mCh-Puro
NCI-H125
NCI-H125-Luc
NCI-H1299
NCI-H1650
NCI-H1703
NCI-H1703-Luc-mCh-Puro
NCI-H1975-Luc
NCI-H2110
NCI-H2122
NCI-H441
NCI-H460-Luc2
NCI-H522
PC-9
Human
Lung [SCLC]
DMS 114
NCI-H446
NCI-H69
NCI-H82
SHP-77
Human
Lung [Squamous]
EBC-1
SK-MES-1
Human
Mammary/Breast
Mammary/Breast
BT-20
BT-474
Hs 578Bst
Hs 578T
MCF 10A
MCF7-Luc-mCh-Puro
MDA-MB-231-2LMP
MDA-MB-231-Luc-D3H1
MDA-MB-231-Luc-D3H2
MDA-MB-231-Luc-D3H3
MDA-MB-361
MDA-MB-453
MDA-MB-468
MX-1-Luc
SK-BR-3
T47D
Human
MMTV-PyMT
Mouse
Ovarian Cancer
Ovarian
A2780-Luc
IGROV1-Luc-Mch-Puro
NIH:OVCAR-3
NIH:OVCAR-3-Luc-mCh-Puro
OV-90
OVCAR-4
OVCAR-5-Luc-mCh-Puro
OVCAR-8-Luc-mCh-Puro
SK-OV-3
Human
Mouse
Prostate Cancer
Prostate
22Rv1
CWR-22-R
DU 145-Luc
LnCap clone FGC
PC-3-Luc
PC-3M-Luc-C6
VCaP
Human