In-depth studies with a team well versed in ICH guidelines.
As a part of ICH studies, you may need to do more in-depth studies on the core battery organ systems. Here are some of the ways we go further to better understand the impact of your molecule on the heart:
- hERG trafficking assay
- Cardiac contractility (LVP)
- Langendorff Isolated Heart model
- Purkinje fiber assay
Supplemental studies can also be conducted on the GI, renal and CNS systems — including abuse and seizure liability assessment.