Discovery Support

Address liabilities pertaining to both cardiovascular — and non-cardiovascular — targeted drugs, earlier than ever before. “Frontloading” your program is a process where you address cardiovascular or seizure liability safety endpoints prior to the selection of your drug candidate. Although not mandated by the key regulatory guidance for safety pharmacology, an increasing number of companies choose to conduct early non-GLP safety studies in support of decisions on the progression of their compounds. These studies can be incorporated in Lead Optimization toxicology programs or integrated with mechanistic endpoints.

Cardiovascular testing equipment used at Covance.
  • Cardiovascular telemetry in rodents, ferrets and large animals
  • EEG – telemetry, surface electrodes
  • Investigative and Neurotoxicology studies