In toxicologic pathology this foundational role extends to the assessment of the safety of a drug, compound, device or vaccine. The pathologist identifies, characterizes and manages risk versus benefit.
Pathologists provide a foundational role in exploring the causes and effects of a disease using samples of body tissues or fluids.
What's the difference between anatomic & clinical pathology?
- Analytic evaluations conducted on samples collected from humans and necropsied animals
- Tissue examination
- Nonclinical studies (GLP & non-GLP); only evaluation that will not be repeated in clinical studies
- Single endpoint
- Analytic evaluations conducted on samples collected from living humans and animals
- Fluid examination
- Nonclinical or clinical study (see clinical testing services)
- Multiple collections possible during a study (depending on species)
- LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits. (NCBI)
- Scientific and Regulatory Policy Committee Points to Consider*: Approaches to the Conduct and Interpretation of Vaccine Safety Studies for Clinical and Anatomic Pathologists (NCBI)
- Atlas of Normal Microanatomy, Procedural and Processing Artifacts, Common Background Findings, and Neurotoxic Lesions in the Peripheral Nervous System of Laboratory Animals (NCBI)