Genetic Toxicology Studies
For more than 30 years, we’ve worked with a wide range of industries to successfully assess the potential for genetic damage or identify genotoxic impurities in compounds.
More than 100 scientists offer genetic tox services from our global centers of excellence
State-of-the-art GLP study designs based on the most up-to-date guidelines
Broad experience with many non-standard investigative assays
Evaluating the genetic toxicity of a drug or chemical is a journey. Make smarter decisions faster with unique perspectives that save you time and resources. Our team helps you navigate the draft ICH M7 and new OECD guidelines. We deliver solutions such as centromere probing of micronuclei, 3D skin models, as well as in vivo comet and transgenic Muta™Mouse assays. These unique solutions enable us to help you gain genetic insights about your molecule that most other CROs can’t help you obtain.
Did you know that you can get our globally recognized genetic toxicology services from any of our world-class facilities? We have purpose-built genetic toxicology centers of excellence in Greenfield, IN, Harrogate, UK and Porcheville, France. You partner with a team of more than 100 genetic toxicology specialists, including many study directors with more than 20 years of experience in the field. Working with you, we create a clearer picture of any potential genotoxic risk.
Consider some of our standard battery of tests that meet ICH or OECD requirements:
In vitro assays
- Ames, mammalian gene mutation (mouse lymphoma assay)
- Chromosome aberration (human lymphocytes and CHO cells)
- Micronucleus (human lymphocytes and cell lines)
In vivo assays
- Rodent bone marrow micronucleus and chromosome aberrations
- Comet and combination (micronucleus and Comet)
We specialize in non-standard assays too — enabling you to better understand issues that arise during the discovery or development phases. These investigative assays give you a quick way to address and resolve issues with lead candidates as you move through the development journey.
Whether you need assays to meet regulatory requirements, affordable screening studies or highly efficient multi-endpoint assays, you partner with a large and diverse team of toxicologists who specialize in assessing genetic risk. Our primary services: