Toxicity studies: Acute
Acute Toxicity Studies evaluate short-term serious adverse effects after clinical and parenteral administration either as a single dose or in multiple doses during 24 hours.
The test uses two mammalian species, including one non-rodent, and provides the following information:
- Potential for acute toxicity in humans
- Potential for toxicity against the target organs
- The time course of drug-induced effects
- An appropriate dosage for multiple-dose toxicity studies
- Species differences in toxicity
Data on acute toxicity can predict the outcome in human overdose and supports Phase III clinical trials.