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Showing results 1057 - 1072 of 91813 for .

Showing results 1057 - 1072 of 91813 for .

A Comparative Evaluation of Environmental Samples from Food Manufacturing Plants with the Atlas™ Listeria Detection Assay on Atlas System, DuPont Qualicon BAX® System PCR 24E Assay, and ...
IAFP 2012 - Listeria is an environmentally ubiquitous organism implicated as a major cause of human foodborne illness worldwide. In the food industry, and more speci cally in manufacturing plants producing foods associated with listeriosis, contamination prevention is a primary concern. In order to preclude end product contamination with the human pathogen Listeria monocytogenes, environmental monitoring is an essential component of a food processing plant's Hazard Analysis and Critical...
A Comparative Evaluation for Listeria monocytogenes in Food with the Atlas™ Listeria Detection Assay on Atlas System and DuPont Qualicon BAX® System PCR 24E Assay
IAFP 2012 - Listeria is an environmentally ubiquitous organism implicated as a major cause of human foodborne illness worldwide. In the food industry, and more speci cally in manufacturing plants producing foods that have been associated with listeriosis outbreaks, the release of contaminated nished product with the human pathogen Listeria monocytogenes is a primary concern
The Development and Validation of an Ultra-sensitive ELISA Method for the Determination of Tartrate-Resistant Acid Phosphate 5 (TRAP) in Human Serum
AAPS-NBC 2014 - Tartrate-resistant acid phosphatase, or acid phosphatase 5 tartrate resistant (TRAP or ACP5), is a glycosylated monomeric metalloenzyme expressed in mammals. In this poster, we report on the development and validation of an ultra-sensitive method for this analyte that may be used in the support of clinical trials.
Validation of 6- and 24-Well Plate Bacterial Mutagenicity Assays
ACT 2016 -- Genotoxicity of new chemical entities (NCEs) provide an early indication of possible carcinogenic activity. Regulatory agencies recommend testing for genotoxic potential prior to initiation of human clinical trials and/or subsequent marketing of NCEs. Earlier genotoxicity testing is beneficial to reduce mutagenicity-related late stage attrition while minimizing resource expenditure. The 6- and 24-well plate formats are miniaturized versions of the standard plate Ames assay that...
Step-wise Strategy for Minimizing Drug Interference in Immunogenicity Testing for Therapeutic Biologics
AAPS-NBC 2014 - Biologic drugs commonly elicit immune responses, resulting in anti-drug antibodies (ADA) that can cause a variety of clinical consequence. We describe here a step-wise approach to optimize the acid pretreatment of samples without compromising the ADA activity detected using a MSD® bridging format assay for immunogenicity testing.
2014 Validation MSD V-PLEX.indd
AAPS-NBC 2014 - This work was designed to further validate the human Proinflammatory Panel 1 V-PLEX PLUS biomarker assay system launched by Meso Scale Discovery (MSD®)...
Companion and Complementary Diagnostics for PD-L1 Expression Assessment in Non-Small Cell Lung Cancer
ASCO 2016 -- PD-L1 expression has been an important biomarker used in the evaluation of patient samples for the consideration of treatment with checkpoint inhibitors such as KEYTRUDA®, OPDIVO® and TECENTRIQ™. While other biomarkers such as mutational burden, genetic alterations resulting in neo-antigens, genomic instability, and blood based markers of immune function have also been investigated, PD-L1 expression continues to be a primary means of assessing for the potential patient response...
Analysis of B-Vitamins by LC-MS/MS in Infant Formula and Dietary Supplements
AOAC INTERNATIONAL 2014 - Analytical methods for analysis of B vitamins have changed little over the years. While some chemical analysis methods exist, microbial analysis methods for individual B vitamins have been the standard since the early-to-mid 1900s. These methods determine bio-available levels of B vitamins based upon actual biological uptake.
Screening and Identification of Adulterants in Weight Loss Supplements by UHPLC and High-Resolution Accurate-Mass Detection
North American Chemical Residue Workshop, NACRW 2015 - The dietary supplement market segment has been growing worldwide at 5% or more year over year for an extended period of time. One particularily popular category is weight-loss products. Unfortunately, these products are sometimes adulterated with synthetic weight-loss drugs that have anorectic or laxative effects (such as sibutramine and its analogs) and also with antidepressants to suppress side-effects of these drugs.
Screening and Identification of Adulterants in Weight Loss Supplements by UHPLC and High-Resolution Accurate-Mass Detection
Recent Advances in Food Analysis (RAFA) 2015, 7th International Symposium - Therefore, screening and identification of a wide range of adulterants are prerequisites for many supplement distributing companies to ensure consumer safety, comply with regulations and protect their brand. We developed a high-resolution/accurate-mass screening and identification method using a Q ExactiveTMPlus (Thermo Fisher) instrument, which provides a wide analytical range allowing for detection of both very...