Search

By Industry Solutions (2)
By Phase (1)
By Molecule Type (1)
By Therapeutic Area (3)
Covance Events (9)
Geography (3)
Keywords (10)

Filters

Showing results 1041 - 1056 of 91813 for .

Showing results 1041 - 1056 of 91813 for .

Population Pharmacokinetic/Pharmacodynamic Modeling of the Effects of Moxifloxacin on QTc Prolongation in Male Cynomolgus Monkeys with ECG Data Collected Using JET-BP
AAPS 2015 - Prolongation of the QT interval in the clinic has been associated with the development of potentially fatal Torsades de Pointes arrhythmias. The purpose of this study was to characterize the population pharmacokinetics and pharmacodynamics of moxifloxacin after oral administration to male cynomolgus monkeys with ECG data collected using jacketed external telemetry with blood pressure measurement (JET-BP), and evaluate the suitability of JET-BP for detection of drug-treatment...
Improved Sensitivity for the Selective Quantitation of LTB4 in Human Plasma and Sputum via UPLC-MS/MS
AAPS 2014 - Leukotriene B4 (LTB4) is one of a family of eicosanoid inflammatory mediators recognized in numerous disease states. For this reason, LTB4 is used as a pharmacodynamics biomarker and a therapeutic target for the treatment of various inflammatory diseases...
Improved Sensitivity for the Selective Quantitation of LTB4 in Human Plasma and Sputum via UPLC-MS/MS
ASMS 2014 - Leukotriene B4 (LTB4) is one of a family of eicosanoid inflammatory mediators recognized in numerous disease states. For this reason, LTB4 is used as a pharmacodynamics biomarker and a therapeutic target for the treatment of various inflammatory diseases...
Correlation of Beckman Coulter DxI's Total Serum IgE Measurement with Siemens ADVIA Centaur® and Phadia ImmunoCAP® Platforms
AACC 2016 -- The measurement of serum IgE aids in the diagnosis and management of atopic allergic disease and hyper-IgE immunodeficiency syndromes. Total IgE is measured on several FDA approved platforms by immunoassay technique. Beckman Coulter DxI is one of the widely used platforms for Total IgE measurement. Recently Beckman Coulter has announced their decision to discontinue the Total IgE assay kit effective 4th Quarter, 2016. The objective of this study is to determine whether either...
Synergistic Effects of Promoter Associated DNA Methylation and Genetic Alterations to Better Understand Oncogenic Gene Expression Profiles
AACR 2016 -- The impacts of genetic and epigenetic mechanisms on cancer remain enigmatic, especially regarding changes in gene expression and methylation differences between tumor and normal samples. Tumorigenesis can potentially alter DNA methylation, however, the amount and location of these DNA modifications are unknown.
A Comparison of Safety and Pharmacokinetics of Esuberaprost (BPS-314d-MR) in Subjects with Normal, Mild and Moderate Hepatic Impairment
ACCP 2016 -- The prostacyclin analogue beraprost (BPS) consists of a mixture of 4 stereoisomers and is available for treatment of PAH in Japan and other Asian countries. The pharmacologically active isomer esuberaprost (BPS-314d) exerts its pharmacologic actions by specifically binding to PGI2 receptors on smooth muscle, vascular endothelium, and platelets. This leads to vasodilatation, inhibition of platelet aggregation, and antiproliferation. Esuberaprost is undergoing clinical evaluation...
Effect of Steady-State Esuberaprost (BPS-314d-MR) on the Safety, Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Adult Subjects
ACCP 2016 -- The prostacyclin analogue beraprost (BPS) consists of a mixture of 4 stereoisomers and is available for treatment of PAH in Japan and other Asian countries. Warfarin is administered as a racemic mixture of (R)- and (S)-enantiomers and is completely absorbed after oral administration, with peak concentration generally attained within the first 4 hours. The anticoagulant effect of warfarin generally occurs within 24 hours after drug administration. However, the peak anticoagulant...
Detection of Clostridium difficile Toxin in Patient Samples by Cell Culture Cytotoxicity Neutralization Assay (CCNA) Using Isolated Colonies of C. difficile Versus Stool Samples
ASM 2016 -- Clostridium difficile toxin is a common cause of antibiotic associated diarrhea (AAD) and pseudomembranous colitis (PMC). The toxigenic culture method in which organisms are cultured and the stool is tested by the Cell Culture Cytotoxicity Neutralization assay (CCNA) remains the diagnostic "gold standard" for detection of toxigenic C. difficile. This testing should be performed using stool specimen filtrate, however our evaluation shows that when a pure isolate of C. difficile...