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Showing results 1009 - 1024 of 91813 for .

Showing results 1009 - 1024 of 91813 for .

A Highly Selective, Fast and Robust LC-MS/MS Method for the Quantification of Poloxamer 188 in Rat Plasma
ASMS 2014 - Poloxamers are nonionic triblock copolymer surfactants composed of a central hydrophobic chain of polyoxypropylene oxide flanked by two hydrophilic chains of polyoxyethylene oxide. Here, we developed a simple, fast, robust and specific LC-MS/MS assay to quantify poloxamer 188 in rat plasma...
Quantification of Phosphorodiamidate Morpholino Oligomer (PMOplus®) AVI-7288 in Human Urine by LC-MS/MS
AAPS 2015 - Phosphorodiamidate Morpholino Oligomers (PMOs) are synthetic DNA analogs that sterically inhibit gene expression in a sequence-dependent manner. AVI-7288 contains positive charges (PMOplus) that targets the viral messenger RNA (mRNA) encoding the Marburg virus nucleoprotein, a major nucleoprotein involved in RNA encapsidation. Here we report a fast, sensitive, selective and robust LC-MS/MS assay to quantify AVI-7288 in human urine.
Simultaneous Quantification of Prednisone, Prednisolone and Methylprednisolone in Human Plasma by a Simple, Fast, Sensitive and Selective UHPLC-MS/MS Assay
AAPS 2016 -- Prednisone (Pred), prednisolone (Predl) and methylprednisolone (MPredl) have four-five times more potency than the human adrenal hormone, cortisol , and were approved for use in the United States in the 1950s. In this paper, we aim to develop and validate a simple, fast, sensitive, comprehensive and high throughput UHPLC-MS assay for the quantitative analysis of prednisone, prednisolone and methylprednisolone in human plasma.
Doxorubicin and Doxorubicinol: Investigation on the Instability in Human Whole Blood and Full Validation in Human Plasma K2EDTA using LC-MS/MS
AAPS 2016 -- Doxorubicin (DOX) is a highly effective cancer chemotherapeutic drug but its clinical utility is limited by its cardiotoxicity, which may be related to doxorubicinol (DOXol), the major metabolite of DOX. In this paper, we aimed to develop a sensitive HPLC-MS/MS quantitative assay for DOX and DOXol in human plasma (K2EDTA) with a small sample volume (25.0 μL). Additionally, the whole blood stability (WBS) of DOX and DOXol was investigated.
Evaluation of JZP 110 as a Potential Substrate or Inhibitor of a Panel of Human Drug Transporters
AAPS 2016 -- To determine if JZP-110 is a substrate or inhibitor of key human transporters including the Organic Anion Transporter (OAT)1, OAT3, Organic Cation Transporter (OCT)1, OCT2, Organic Anion Transporting Polypeptide (OATP)1B1, OATP1B3, Multidrug and Toxin Extrusion (MATE)1, MATE2‑K, P‑glycoprotein (P‑gp), and Breast Cancer Resistance Protein (BCRP).
In Vitro Assessments of CYP and UGT Induction and UGT Inhibition by JZP-110
AAPS 2016 -- The purpose of this study was to measure the extent of induction of specific human cytochrome P450 (CYP) enzymes (CYP1A2, CYP2B6 and CYP3A) and uridine diphosphate glucuronosyltransferase (UGT) 1A1 following exposure of human hepatocytes to JZP‑110; to compare the effects of JZP-110 with those of prototypical inducers; and to determine the inhibitory potential of JZP‑110 on UGT1A1 and UGT2B7.
Impact of Next Generation Sequencing Capabilities on Genomics Based Research
The advent of Next-Generation sequencing technology has fundamentally altered the approach to biological and clinical questions. This technological revolution has revolutionized genomics and opened up new avenues to expand research and development. Covance Genomics Laboratory is a Illumina Certified Service Provider and offers complete sequencing solutions for a range of applications such as genome sequencing, transcriptions, gene regulation and epigenomics, as well as metagenomics. This...
Case Studies Demonstrating Challenges and Approaches to Selectivity Adjustments for Endogenous Biomarkers in Human Serum with Ligand-Binding Immunoanalysis
AAPS 2014 - There continues to be debate concerning the optimal method used to adjust for endogenous biomarker levels in spiked quality controls (QC), validation samples (VS), and in selectivity determinations following ligand-binding analyses (LBA) with a matrix like normal human serum (NHS)...
Progress Toward Validation of the Meso Scale Discovery (MSD®) V-PLEX™ Proinflammatory Biomarker Panel 1 in Normal Human Serum (NHS)
AAPS-NBC 2014 - This work was designed to further validate the human Proinflammatory Panel 1 V-PLEX PLUS biomarker assay system launched by Meso Scale Discovery (MSD®)...