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Showing results 993 - 1008 of 91813 for .

Showing results 993 - 1008 of 91813 for .

Overcoming Matrix-Based Interferences Using Multi-Extraction Techniques for LC-MS Analysis of AZD0156 and its Metabolite in Human Plasma
ASMS 2017 -- AZD0156 is a potent inhibitor of the Ataxia telangiectasia mutant (ATM) kinase. ATM is a serine/threonine protein kinase that plays a role in the cellular DNA damage response signaling activated by DNA double strand breaks. This compound is being developed as an oral anti-tumor agent in combination with chemotherapy and other novel agents where there is dependency on ATM for signaling in response to double-strand DNA breaks. Due to the potency of AZD0156, it was necessary to...
Assessment of Receptor Occupancy by Flow Cytometry: A Powerful Tool in Therapeutic Discovery
30th Congress of the International Society for Advancement of Cytometry, CYTO 2015
Analysis of Total, Released and Encapsulated AZD2811 from a Nanoparticle Formulation
WRIB 2016 - Nanotechnology has been applied to medicine through the development of alternative drug delivery platforms, including liposomes, nanolipids, nanocrystals, albumin nanoparticles and other platforms. These alternative platforms can offer advantages over conventional formulations, including improved bio-distribution, prolonged systematic exposure and improved therapeutic index. Developing assays to support studies utilizing nanoparticles as a delivery platform presents unique...
Detection of Salmonella in Probiotic Cultures
IFT 2017 -- The objective of this study was to explore the recovery of Salmonella from a background of probiotic cultures and demonstrate and validate an effective, sensitive method for detecting Salmonella in probiotic cultures to protect public health.
A Micro-SPE-LC/MS/MS Quantitative Assay for Phosphorodiamidate Morpholino Oligomer (PMOplus®) AVI-7288 in Human Plasma
ASMS 2016 -- Phosphorodiamidate Morpholino Oligomers (PMOs) are synthetic oligonucleotide compounds that bind to target sequences of RNA by classic Watson-Crick base pairing and can be useful to sterically modify gene expression in a sequence-dependent manner. AVI-7288 is a novel 23 base synthetic phosphorodiamidate morpholino oligomer with five positive charges [PMOplus(R), AVI BioPharma, Inc.] intended as a medical intervention for documented or suspected exposure to Marburg virus.Here,...
Quantifying Sixteen Bile Acids Using LC-HR/AM MS: Improving Selectivity, Sensitivity and Overall Performance
AAPS 2014 - Bile acids (BAs) are a broad group of compounds composed of a four ring steroid structure, a five- or eight-carbon side-chain terminating in a carboxylic acid, and hydroxyl groups on different positions and/or orientation on the steroid rings (Figure 1). They are the major catabolic products of cholesterol and are involved in numerous metabolic processes...
Improving Sensitivity and Throughput for an LC-MS/MS Assay for the Quantification of Buprenorphine, Norbuprenorphine, and Naloxone in Human Plasma
ASMS 2014 - Buprenorphine and naloxone have been widely used as antiabuse medications. A high demand exists from pharmaceutical companies to quantify the primary drug, buprenorphine, its primary metabolite, norbuprenorphine, and a proposed co-formulant, naloxone, at low levels...
An Ultrasensitive Assay for Quantification of a Cationic Lipid, 1,2-Dioleoyl-3-Trimethylammonium Propane, in Mouse Plasma by HPLC-MS/MS
ASMS 2016 -- Lipids are widely used as carriers for delivery of therapeutic molecules by forming liposomes ornanoparticles. 1,2-Dioleoyl-3-trimethylammonium propane (DOTAP) is a synthetic cationic lipid that is widely used in liposomal and nanoparticle drug carrier systems. Here we report an ultrasensitive, fast, selective and robust assay for the quantification of DOTAP in mouse plasma by HPLC-MS/MS with a wide range of 0.05-50.0 ng/mL.
Quantitative Determination of Poloxamer 188 in Rat Plasma Using a Specific and High Throughput LC-MS/MS Method
AAPS 2014 - Poloxamers are nonionic triblock copolymer surfactants composed of a central hydrophobic chain of polyoxypropylene oxide flanked by two hydrophilic chains of polyoxyethylene oxide. Due to poloxamers' amphiphilic structure and absence of toxicity, they serve as excellent vehicles for drug delivery...