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Showing results 17 - 32 of 399 for .

Showing results 17 - 32 of 399 for .

Case Report: Gastric Adenocarcinoma with Bone Formation in CD-1 Mouse
ACVP 2018 -- A control mouse used for a carcinogenicity study presented on day 442 of the dosing phase for debilitating condition (pallor, hunched posture, and discolored black feces). At necropsy, a duodenal intussusception and a large spleen were noted. Microscopic examination revealed a gastric mass at the pyloric junction extending into the duodenum. The glandular stomach had a focal polypoid mass composed of two cell populations; cuboidal to columnar cells forming tubules and solid...
Comparison of Subretinal Injection of iPSC-Derived RPE Cell Suspension or Subretinal Implantation of iPSC-Derived RPE on PLGA Scaffold in RNU Nude Rats
ACT 2018 -- Dysfunction of retinal pigment epithelial cells (RPE) is an important factor in development of age related macular degeneration (AMD). RPE support photoreceptor function, and degeneration of RPE leads to retinal degeneration and vision loss. RPE replacement therapy has the potential to stop such degeneration. An induced pluripotent stem cell (iPSC)-derived RPE implant cultured on a biocompatible poly (lactic-co-glycolic acid; PLGA) scaffold was developed as an RPE replacement...
Assure Future Availability of Nonhuman Primates
Keeping to your research timeline is essential. To stay on track, you need to know that you can procure high-quality nonhuman primates (NHPs) that meet your specifications when and where you need them.
Allowance for Diastolic Interval Distinguishes Na Channel Block in iPSC-Derived Cardiomyocytes
SPS 2018 -- 2D culture of spontaneously active iPSC-derived cardiomyocytes from commercial sources can be used to assess the effects of drugs on human cardiac electrophysiology. The use of voltage sensitive dyes and >10kHz acquisition rates of fluorescence signals using the medium/high through-put system (CellOPTIQ® Clyde Biosciences Ltd) allows the unambiguous assessment of the action potential (AP) waveform in iPSC-CMs. Drug actions on one or more ion channels cause clear changes in the...
Treatment-Related Convulsion in the Absence of CNS Seizure: A Case Study
SPS 2018 -- Many therapeutic compounds may not only elicit CNS seizures or EEG-silent myoclonic events, but may lower a patient's threshold for seizure, thus enhancing seizure liability, which is a significant safety factor in drug development. Not all of these compounds are CNS-active, and there is increasing interest and responsibility to quantify seizure liability within the drug development process. Convulsions are often taken as an endpoint of seizures in nonclinical safety studies...
Optimization of the PTZ-Induced Convulsion Test for Proconvulsant Evaluation
SPS 2018 -- The most commonly used in vivo screening assays for assessing seizure liability are the maximal electroshock and PTZ-induced convulsion models. These are well-characterized and reliable tests for the evaluation of anticonvulsant efficacy. However, they are less effective in assessing proconvulsant risk. Due to the ever-increasing importance of assessing seizure liability of novel therapeutics, the objective of this study was to optimize the PTZ-induced convulsive liability assay...
Are Clinically Relevant Toxicities Inducible and Analysable in the 3-D Human In Vitro Airway Model EpiAirway-FT?: A Proof of Concept Study
ESTIV 2018 -- In the airway epithelium, Goblet cells produce mucus to enable the mucociliary clearance of unwanted particles from the bronchi and trachea. Hyperplasia of goblet cells (GCH) is one of the many respiratory epithelial responses to numerous environmental challenges (e.g. cigarette smoke, air pollution, viral infection) and is commonly observed in respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma. Elevated mucin levels in the airway increase the...
Use of a 3-D Human In Vitro Airway Model (EpiAirway-FT) to Investigate Clinically Relevant Endpoints for Pulmonary Disorders: Proof of Concept
Eurotox 2018 -- Goblet cell hyperplasia (GCH) is a clinical pathology observed as a disturbance to the epithelial cell layer in many locations throughout the body. In the airway epithelium, Goblet cells produce mucus to enable the mucociliary clearance of unwanted particles from the bronchi and trachea. Hyperplasia of goblet cells (and therefore increased mucus production) is one of the many respiratory epithelial responses to numerous environmental challenges and is commonly observed in...
Thrombocytopenia after Repeated Administration of Oligonucleotides in Cynomolgus Monkeys Can Be Treated with Steroids: A Case Report
Eurotox 2018 -- Reduction in platelet counts has been reported in monkeys administered 2ʹ-O-methoxyethyl modified (2ʹ-MOE) antisense oligonucleotides (ASOs). In most cases, the reduction in platelet count is gradual and platelet counts remain in the normal range with continued dosing. However, in a subset of monkeys, thrombocytopenia can be severe (platelet count
Tail Vein Dosing in Cynomolgus Macaques
NC3Rs Primate Welfare 2018 -- With the increased development of biologically based medicines, there is a greater requirement to administer novel pharmaceuticals by IV infusion in macaques. Due to the nature of these materials, it is often necessary to perform infusion over extended periods of up to 2 hrs in order to mimic potential human therapeutic administration.
Genotoxicity Evaluation of Tobacco and Nicotine Delivery Products: Part 1. Mouse Lymphoma Assay
UKEMS 2018 -- Next generation tobacco and nicotine products (NGPs), comprised of tobacco heating products (THP) and electronic nicotine delivery systems (ENDS), have evolved significantly over the last few years and are gaining consumer acceptability. Available in vitro, in vivo and clinical data indicate these products may possess significantly lower biological activity when compared to cigarette smoke, suggesting these products may be of reduced harm, when compared to cigarette smoking,...
Social Housing and Pregnancy Success in the Nonhuman Primate (NHP): An Appraisal
ACT 2018 -- Social housing (more than one animal per cage) of NHPs in the context of animal experimentation has become mandatory in many countries and is expected to gain increasing significance globally in the forthcoming years. In the European regulatory animal welfare environment, pair or group housing is the default for NHP husbandry (Council of Europe 2007). Following various setups and attempts to co-house pregnant animals, it was decided to move to default social housing of pregnant...
Stereotactic Surgeries and MRI-Guided Convection-Enhanced Delivery (CED) into the Striatum in Cynomolgus Macaques
Eurotox 2018 -- Gene therapy is a promising area of drug development for a number of diseases including neurological disorders. As part of the development of gene therapy products, regulatory toxicity studies for a viral vector (BSL-1) require its delivery into a discrete area of the brain of cynomolgus macaques (Macaca fascicularis) and include subsequent monitoring of the animals for a period of 26 weeks. Because cynomolgus macaques show a high nucleotide sequence homology with humans,...
Pole-and-Collar Training of Chlorocebus Monkeys for Ophthalmic Study Purposes
National AALAS & APV 2018 -- At our preclinical research facility, pole-and-collar training is used for macaques to facilitate handling, especially in combination with chair restraint for dosing or procedures. Animals undergo a period of training to acclimate them to come to the front of the cage, sit quietly and then have a pole clipped to their collar. Animals are then trained to exit the cage for study purposes such as sitting in a restraint chair. Pole-and-collar training allows...
PhysioTel M-Series Telemetry is a Viable Alternative to Jacketed Telemetry for Continuous Cardiovascular Data Collection on Toxicology Studies
SPS 2018 -- There are cases where it is of clear benefit to replace or augment a single dose cardiovascular study with the addition of cardiovascular endpoints to a toxicology study. Jacketed external telemetry (JET) with the addition of a rodent blood pressure (BP) transmitter is commonly used to collect electrocardiography (ECG) and BP data on a toxicology study. While JET enables data collection from freely moving animals, the stress of wearing jackets can cause animals to display higher...
Access High Quality on Our Nonhuman Primates
Today's more complex studies, as well as increases in development of biologics and personalized medicine, require more precise model selection for nonhuman primates (NHPs). To keep your research on track, you need to know you're getting models that meet your specifications.