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Showing results 257 - 272 of 91813 for .

Showing results 257 - 272 of 91813 for .

Functional and Structural Effects of Subretinal Dose Delivery in Mice
Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) 2015
Determination of a No Observable Effect Level (NOEL) for Endotoxin following a Single Intravitreal Administration to Cynomolgus Macaques
ARVO 2017 -- The presence of endotoxin in intravitreal formulations is a concern and prompted the recent characterization of the ocular response to intravitreal endotoxin in the rabbit. Development of biologics often requires the use the nonhuman primate (NHP) as the only relevant species. Thus, defining a NOEL and characterizing the relationship of endotoxin dose to ocular inflammation in the NHP is important because it will aid interpretation of ocular safety data. The objective of this...
Successful Islet Isolation from Canine Pancreata Procured Post-Circulatory Death and After Extended Cold Ischemia Time
National AALAS 2015 - Diabetes mellitus is one of the most common endocrine disorders of dogs and cats and is caused by failure to adequately control blood glucose due to loss or dysfunction of pancreatic beta cells.
Oligonucleotide Drug Development
This presentation covers the following ares related to oligonucleotide nonclinical drug development for a diverse range of therapeutic indications: strategy development, regulatory approvals, and best practices in the conduct of CNS-administered oligonucleotides.
Advances in Animal Welfare and Scientific Outcomes of the Bile Duct Cannulated Rat Model Utilised in ADME Studies
DMDG 2016 -- Rats are typically the rodent species of choice for investigating the absorption, distribution, metabolism and excretion of new chemical entities. Since rats lack a gall bladder, they are an ideal model for investigating continuous biliary excretion and biotransformation in this common toxicological species. The design and implementation of a modified tail cuff and cannula system introduced at Covance permits the animal's own bile to be re-routed back into the duodenum during...
Take Your Child to Work Day in an Animal Research Facility? Improving Perceptions Using Three Es: Education, Engagement and Enrichment
ACT 2015 - Children are regularly exposed to many views about animals in research, whether at school, through peers or media sources. These views affect their perceptions of animals in research. Participation in Take Your Child to Work Day allows animal research facilities to provide children with positive experiences involving animal research.
Global DART Capabilities
Primate Symposium 2010
Ovarian Cacinoma in NHP
APV Symposium 2013