Preclinical Oncology

Advance your preclinical oncology compounds with a comprehensive suite of preclinical oncology studies, including in vitro and in vivo pharmacology efficacy models, in vivo imaging technologies as well as focal radiation capabilities. 

When your research has the potential to save lives, you deserve a partner with the oncology pharmacology knowledge, breadth of tools and experience to move life-changing drug candidates through non-GLP, preclinical development and oncology clinical trials quickly and efficiently.  

We've helped hundreds of companies discover their next life-improving compound. 

Preclinical oncology research services

Cell Lines & Tumor Models

Cancer growth curves and cell line list

Immunotherapy & Adoptive Cell Therapy Support

We offer over 30 different syngeneic tumor models, from both solid and disseminated origins, to provide you with many choices to further your immuno-oncology research. We are continually improving and expanding adoptive cell therapy capabilities:

Flow Cytometry, Imaging and Radiation

 

For over a decade, we have offered an industry-leading array of in vivo imaging modalities for optimum pharmacologic interrogation when needed. These include:

Immunotherapies for oncology drug development

Preclinical Oncology Resources

Spotlight:

LL/2: An Immunosuppressive Murine Tumor Model

Lung cancer is the second most common cancer diagnosed in both men and women in the United States and is, by far, the most common cause of cancer-related deaths in men and women. In 2019, the American Cancer Society estimates that 228,150 new cases of lung cancer (116,440 in men and 111,710 in women) will . . . Read more about the LL/2 model

Spotlight:

B16-F10: A Murine Melanoma Model

Skin cancers include carcinomas of all layers of the skin with the most common being basal cell (BCC) and squamous cell carcinomas (SCC). Melanoma and non-melanoma skin cancers (Merkel cell carcinoma, Kaposi sarcoma, cutaneous lymphoma and other sarcomas) are much less common. . . . Read more about a murine melanoma model

Poster:

Preclinical Models of Multiple Myeloma

Multiple myeloma is a clonal B cell malignancy characterized by the accumulation of terminally differentiated, antibody-producing plasma cells in the bone marrow that is invasive and drug resistant. Patients are generally asymptomatic until very late state disease. There are few preclinical models that recapitulate human disease. In this work, we have evaluated the human MM.1S model and the murine 5TGM1 model . . . Read more about the preclinical models of multiple myeloma

Poster:

In-Depth Myeloid Cell Characterization in the Murine Syngeneic CT.26 Colon Carcinoma Model by 10-Color Flow Cytometry

The efficacy of immune-modulating anti-cancer therapeutic antibodies that have been FDA-approved in recent years, such as anti-CTLA-4 and anti-PD-1, has driven growing interest in methods that provide a mechanistic understanding of drug function. . . Read more about In-Depth Myeloid Cell Characterization

About Preclinical Oncology

In 2019 Covance welcomed the preclinical pharmacology oncology provider, MI Bioresearch, into the Covance family. You can now access hundreds of cell line assays and tumor models, as well as thousands of potential oncology patients for clinical trials or explore an extensive library of oncology diagnostics

Preclinical Oncology Events