Respiratory Syncytial Virus (RSV) lung infection

Discovery

Respiratory Syncytial Virus (RSV) infection is common (over 80% of infants will have been infected with RSV by the age of two). In most cases this is a mild upper respiratory tract infection but can lead to hospitalization in approximately 30 % of babies (< 6 months old) and 10 % of those aged over 65. It is the largest cause of bronchiolitis.

A mild disease state can be induced in both immunocompromised and non-immunocompromised mice with recoverable levels of RSV form the lung and increased inflammatory cells.

For the assessment of antivirals we have an on-site microbiology Department who will prepare, assess the viral dose and can assess viral load in the lung tissue.

Study Design
Species/Strain	Balb/c mouse (immunocompromised)
Model	RSV lung infection model
Relevant Use	Screening and assessment of new anti-viral and anti-inflammatory drugs for viral respiratory disease
Readouts Available	Daily Bodyweights and Clinical Signs, Lung Function (penH, Resistance, Compliance, FEV), Viral load, BAL differential cell counts, BAL cytokines and Pathology

Study data generated by Labcorp Huntingdon Pharmacology.

Molecule or Product Type

Biologics, Small Molecule

Models

Mouse

Administration Routes

Dermal, Dietary, Gavage, Implant, Infusion, Inhalation, Intracranial, Intracutaneous, Intramuscular, Intranasal, Intraperitoneal, Intrathecal, Intratracheal, Intravenous, Ocular, Rectal, Subcutaneous, Transcortical, Vaginal

Regulatory

IND & CTA, NDA & BLA, Post-Market

Industry Market

Pharma

Phase

Discovery, Nonclinical

Related Models

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