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Methicillin-resistant Staphylococcus aureus (MRSA) neutropenic thigh infection model
Methicillin-resistant Staphylococcus aureus (MRSA) is an opportunistic pathogen that is currently accounts for the majority of skin and soft tissue infections (SSTIs) in the United States. As mice are less susceptible to S. aureus infection they are first made neutropenic.
The neutropenic thigh infection model is an ideal PK/PD model for the assessment of the efficacy of novel antibiotics and antimicrobials. In this model there is tissue burden for a minimum of 24 hours which is significantly reduced by subcutaneously administered Vancomycin.
| Study Design | |
|---|---|
| Species/Strain | CD-1 mouse |
| Model | Methicillin-resistant Staphylococcus aureus (MRSA) neutropenic thigh infection model |
| Relevant Use | Efficacy of novel antibiotics and antimicrobials |
| Readouts Available | Daily Bodyweights and Clinical Signs, Bacterial load, systemic cytokines and Pathology |
Study data generated by Labcorp Huntingdon Pharmacology.
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