Model of Allergic Bronchopulmonary Aspergillosis (ABPA) in Mice

Discovery

Aspergillus is a common filamentus fungi and infection can result in three main types of bronchopulmonary aspergillosis; invasive aspergillosis, chronic aspergillosis, and allergic aspergillosis. Allergic

Mice are administered fungi suspended in agarose beads; a persistent fungal presence is observed for a minimum of 21 days after administration. Low level fungal presence and allergic responses are confirmed by measurable levels of BAL galactomannan and serum IgE respectively.

Image 1: Fungal Spores are embedded in agarose beads. Picture taken at magnification x 400

Image 2: Galactomannan (A biomarker of fungal infection, used in the clinic) is statistically significantly raised compared to the sham control group, confirming that there is an active fungal infection.

Study Design
Species/Strain	C57BL/6J mouse
Model	Allergic aspergillosis in mice
Relevant Use	Efficacy of novel antifungals for ABPA
Readouts Available	Daily Bodyweights and Clinical Signs, serum IgE, fungal load, BAL differential cell counts, BAL cytokines and Pathology (H&E and PAS)

Study data generated by Labcorp Huntingdon Pharmacology.

Molecule or Product Type

Biologics, Small Molecule

Models

Mouse

Administration Routes

Dermal, Dietary, Gavage, Implant, Infusion, Inhalation, Intracranial, Intracutaneous, Intramuscular, Intranasal, Intraperitoneal, Intrathecal, Intratracheal, Intravenous, Ocular, Rectal, Subcutaneous, Transcortical, Vaginal

Regulatory

IND & CTA, NDA & BLA, Post-Market

Industry Market

Pharma

Phase

Discovery, Nonclinical

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