In Vitro Alternative Test Methods

Crop Protection

Covance are committed to driving the 3Rs agenda and therefore we are continuing to expand and innovate our in vitro testing for the assessment of crop protection products. By partnering with us you will benefit from both our vast experience conducting standard techniques as well as our novel solutions. We’ll create an approach tailored to your regulatory needs and aligned to your substance’s specific properties.

In Vitro

Proven expertise in delivering high-quality in vitro safety assessments

  • Over 20 years’ experience in designing and conducting a comprehensive suite of in vitro tests to globally recognized standards
  • Innovators in in vitro study design and technology: enhancing study reliability and improving outcomes
  • Insights gathered from worldwide regulatory environments leveraged to smooth the regulatory journey of your crop protection product

Your Needs

In vitro safety assessments

Multiple in vitro test methods are available for ascertaining the potential impact of your crop protection product on human safety; however how do you find the optimum approach to meet your needs? How can you best exploit in silico and in vitro testing to answer regulatory questions and meet ever-changing endpoints? You need a partner with insight and experience in in vitro test methods and their application to different global regulatory environments..


Our Capabilities

Covance is at the forefront of in vitro testing for crop protection products

Covance has played a role in validating various in vitro technologies. Staff engage proactively with the in vitro scientific community via membership of a range of professional bodies such as the in vitro toxicology society (IVTS), in vitro testing industrial platform (IVTIP) and the European Society of Toxicology In Vitro (ESTIV).

This puts Covance at the forefront of in vitro methodologies and innovations, generating insights that benefit you as our partner.

Partner with an expert team dedicated to delivering in vitro testing success

The Covance in vitro testing team comprises experts from varied backgrounds with extensive experience in planning and managing in vitro tests. The team includes toxicologists, biologists, analytical chemists and environmental scientists. By working collaboratively, study plans can be flexed and optimized to meet your needs and timelines.

Let Covance leverage their extensive in vitro testing capabilities to reliably characterize the safety profile of your crop protection product

Covance conducts approximately 400 in vitro toxicology studies each year covering the following:

Phototoxicity

Balb/c 3T3

OECD 432

Cytotoxicity

Balb/c; L929; MRC5

ISO/ICCVAM/HC

Skin Corrosion

3D models

OECD 431

Corrositex®

OECD 435

Skin Irritation

3D models

OECD 439

Eye Irritation

BCOP

OECD 437

Isolated Chicken Eye Test (with optional histopathology)

OECD 438

EpiOcular™

OECD 492

Skin Sensitization

Direct Peptide Reactivity Assay (DPRA)

OCED 442C

KeratinoSens™ Assay

OCED 442D

Human Cell Line Activation Test (hCLAT)

OCED 442E

 Endocrine Disruption

Estrogen receptor agonist/antagonist

OECD 455

H295R Steroidogenesis assay

OECD 456
Androgen receptor (AR Calux®) agonist/antagonist OECD 458

Human Recombinant Estrogen Receptor (hrER)

OECD 493

*In vivo skin sensitisation (OECD 429) can be offered when justified