Physicochemical Properties of Active Ingredients

Crop Protection

It is essential to characterize and understand the basic physicochemical properties of your Pure Active Ingredient (PAI) or Technical Grade Active Ingredient (TGAI). All active ingredients require their physicochemical properties to be characterized. Covance has been helping customers to assess and characterize their active ingredients for over 50 years. With vast experience working on difficult to handle substance, Covance can help you with both complex and simpler tests tailored to your requirements.

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  • Extensive and flexible capacity and facilities allowing rapid turnaround
  • Cross-functional scientists dedicated to excellence in characterizing standard and non-standard substances
  • A comprehensive suite of physicochemical tests, including all routine general and hazardous assessments

 

Your Needs

How to establish basic physicochemical parameters in a timely manner

Common tests for basic physicochemical parameters of active ingredients are straightforward to run. However, some active ingredients can be difficult to handle and need unique approaches. For example, active ingredients with high volatility, poor solubility or  which require a specific detection type – all need a tailored approach. 


Our Capabilities

Extensive experience of standard and difficult-to-handle active ingredients 

Our combination of extensive facilities and dedicated analytical chemists ensures your needs are met, no matter how complex the active ingredient. A suite of the standard physicochemical tests for pesticide active ingredients are available:

  • Analytical profile of batches
  • Appearance
  • Boiling Point
  • Dissociation Constant
  • Henry’s Law Constant
  • Melting/Freezing Point
  • Partition Coefficient
  • Relative Density
  • Spectra
  • Surface Tension
  • Partition Coefficient
  • Vapour Pressure
  • Water Solubility

In addition, we can characterize the hazardous properties of your active ingredient. Our team can support a range of studies:

  • Explosive Properties
  • Flammability Studies including:
    • Liquids by flash point
    • Solids by UN N.1
    • Auto-ignition by A15
    • Self-ignition/self-heating by UN N.4
    • Contact with water UN N.5
  • Oxidising Properties to UN O.1 and O.2
  • Pyrophoric Properties to UN N.2 and N.3
  • Corrosion to metals UN C.1

High-specification, extensive analytical capability

We have extensive facilities, fully equipped with a wide range of analytical equipment:

  • HPLC (UV, FLD, RI, MS, ELS, DAD)
  • GC (FID, NPD, ECD, FPD, MS)
  • IR
  • UV/Vis
  • Molecular Weight Distribution
  • Auto-titration
  • Ion Chromatography
  • ICP-MS
  • NMR (subcontracted)

Five batch analysis

For five batch analyses tests, all methods are validated for linearity, accuracy, precision, repeatability, limit of quantification/detection and specificity to ensure high-quality and robust test data.