Inhalation Toxicology

Chemical Testing

Exposure to a chemical through accidental inhalation poses a potential risk to human health including worker safety. The exposure could pose an acute risk or lead to longer term effects of these toxicants, particularly for the respiratory system. Other aspects include development and/or reproduction.

Covance can provide inhalation toxicology services for a broad range of safety assessments, be they standard studies or novel ones requiring innovative approaches and unique delivery devices.

Inhalation_toxicology

Benefit from Covance’s expertise and innovative approaches in inhalation toxicology 

  • Over 40 years' experience performing inhalation studies to recognized worldwide standards, on standard chemicals, difficult to handle and hazardous materials including nanomaterials.
  • A reputation for innovating in both study design and delivery mechanisms to optimize inhalation toxicology study success.
  • Dedicated teams of inhalation toxicology experts including aerosol technicians, specialist animal technicians, engineers, pathologists lead by inhalation science toxicology experts.

 

Your Needs

Inhalation toxicology studies can provide unique and complex challenges

Planning and managing any toxicology study can be daunting; however, inhalation toxicology studies pose unique challenges and complexities. You need to tailor studies to your chemical and optimize them for physiochemical properties and the required regulatory endpoints. You may need to refine standard test approaches to ensure study integrity. This means partnering with a team you can trust to design and manage your inhalation toxicology studies in a way that is right for you and your chemical.


Our Capabilities

An inhalation toxicology team with extensive and diverse expertise

The Covance inhalation toxicology team consists of a range of experts from diverse backgrounds and with extensive experience in planning and running inhalation toxicology studies. The team includes engineers, aerosol technologists, animal welfare specialists, vets, chemical analysts, pathologists and inhalation science toxicology experts.

Performing recognized inhalation studies to deliver reliable results

Covance has experience in performing common inhalation toxicology studies such as:

  • Acute to carcinogenicity
  • Cardiotoxicity to assessing anesthetic potential
  • Studies with specific approaches and dosing up to 24 hours/day
  • Embryofetal to two-generation reproductive studies

Innovating to address your specific challenges and optimize results

Sometimes standard approaches don’t work — that’s when our ‘first of a kind’ inhalation toxicology mindset can help devise a solution suited to your unique challenge. This may be to address unusual endpoints or in the use of non-standard animal species. Alternatively, it may mean customizing inhalation delivery equipment to optimize data quality. This could be via custom-built inhalation chambers or even by 3D printing face masks specific to individual test animals. As your partner, Covance can innovate and enhance standard study approaches to optimize them for your chemical.

Utilizing state-of-the-art analytical techniques and facilities to produce high-quality data

Working hand-in-hand with analytic scientists, the inhalation toxicology team ensures high quality data is produced in an appropriate timescale. Analytical approaches used include GC, IR, UPLC and HPLC analysis and compound specific analysis.

High welfare standards assured for a wide range of common and uncommon species

Covance is proud of the high welfare standards observed in all our in vivo work and especially in inhalation studies where a broad range of common and uncommon species may be required. An expert team of animal technicians and veterinarians conduct in vivo studies to ensure the highest levels of animal care. Inhalation studies can be performed on the following species:

  • Mouse
  • Rabbit
  • Dog
  • Minipig
  • Pygmy goat
  • Cow