In Vitro Safety Assessment

Chemical Testing

In vitro testing for chemical safety assessment is increasingly important as animal use continues to be replaced, refined and reduced. Covance is helping lead innovation in this area. By partnering with us you will benefit from extensive experience in standard techniques and novel solutions. Our goal is to provide an approach tailored to address your regulatory needs and aligned to your substance’s specific properties.

In Vitro

Proven expertise in delivering high quality in vitro safety assessments

  • Over 20 years’ experience in designing and conducting a comprehensive suite of in vitro safety assessments to globally recognized standards
  • Innovative approaches to in vitro safety assessment study design and technology: enhancing study reliability and improving outcomes
  • Insights gathered from worldwide regulatory environments leveraged to smooth the regulatory journey of your chemical 

Your Needs

In vitro safety assessments

A vast array of in vitro safety assessments may be employed to determine the potential impact that your chemical has on human safety. With an increased focus on expanding and exploiting in silico and in vitro testing to answer regulatory questions and meet ever-changing endpoints, you need a partner with insight and experience in both in vitro safety assessment and its application to regulatory requirements from around the globe.


Our Capabilities

Covance is at the forefront of in vitro safety assessment   innovation

Covance is an active participant in international development trials for in vitro technologies coordinated by FRAME, EURL ECVAM and ICVAM. In addition, Covance is a member of the in vitro toxicology society (IVTS) and in vitro testing industrial platform (IVTIP) and European Society of Toxicology In Vitro (ESTIV).

This puts us at the forefront of in vitro methodologies and innovations, generating insights that benefit you as our partner.

Partner with an expert team familiar dedicated to delivering in vitro safety assessment success

Our in vitro safety assessment team consists experts from diverse backgrounds with extensive experience in planning and managing in vitro studies. The team includes toxicologists, biologists, analytical chemists and environmental scientists. By working collaboratively, study plans can be flexed and optimized.

Let Covance leverage their extensive in vitro testing capabilities to reliably characterize the safety profile of your chemical 

Covance conducts over 400 in vitro toxicology studies each year covering the following:

Phototox

Balb/c 3T3

OECD 432

Cytotox

Balb/c; L929; MRC5

ISO/ICCVAM/HC

Skin Corrosion

3D models

OECD 431

Corrositex

OECD 435

Skin Irritation

3D models

OECD 439

Eye Irritation

BCOP

OECD 437

ICE

OECD 438

EpiOcular

OECD 492

Skin Sensitisation

DPRA

OCED 442C

KSA

OCED 442D

hCLAT

OCED 442E

Skin Sensitisation (in vivo)

in vivo

OECD 429

Endocrine Disruption

Estrogen receptor agonist/antagonist

OECD 455

H295R Steriodogenesis assay

OECD 456

BG1Luc estrogen receptor

OECD 458

Human Recombinant Estrogen Receptor (hrER)

OECD 493