Crop & Chemical Product Testing

Gain deep scientific experience in toxicology, metabolism, hazard awareness and environmental fate, paired with global regulatory consulting to meet crop protection and chemical guidelines from agencies like the EPA, REACH and OECD. From herbicides and insecticides to biofuels, fatty acids, enzymes and cosmetics, we can help you to navigate the complex world of chemical testing and crop protection. 

Global Regulatory Consulting & Facilities

  • European Union: ECHA (REACH) / MET (REACH-ICFC) / OECD

  • European Countries: UK MHRA / ANSM / COFRAC / BfARM



Access more than 3M square feet of GLP-compliant, AAALAC-accredited research facilities in Europe, Asia and North America for your single or large-scale, long-term regulated program. 

Dedicated REACH facilities & regulatory offices in the EU have led to more than 100 REACH registration dossiers successfully being submitted to ECHA.

Crop & Plant Protection Testing


Human and enviornmental hazard exposure & assessments

Chemical & ENDS Testing


Biofuels, fatty acids, enzymes, cosmetics and ENDS testing.  

Study Overview for Crop & Chemical Testing

From regulatory support and consulting to your standard toxicology study, we can help. Below is a sampling of the types of assays and studies typically utilized in crop protection and chemical testing. Custom study types are also available. 

Don't see your product? Contact us to learn about other product testing, including lifecycle development for medical device and diagnostics. 

In Vitro Safety Assessment & Metabolism

In Vitro Toxicology Assays

  • Skin sensitization
  • Ocular damage
  • Skin corrosion and irritation
  • Cytotoxicity & phototoxicity
  • Direct peptide reactivity assay 
  • In vitro screening assays (EPA Tier 1) for endocrine disruptors 

OECD #: 428, 431, 432, 437, 439. 

In Vitro Genetic Toxicology

  • Bacterial mutation (Ames) 
  • In vitro micronucleus
  • In vitro chromosome aberration
  • Gene mutation at tk and hprt loci 
  • Mechanistic investigations (FISH, CREST)
  • In vitro 3D skin micronucleus
  • In vitro aerosol testing

In Vitro Metabolism 

  • In vitro species comparison, protein binding, transporter enzyme investigations and ADME studies
  • Profiling and identification of metabolites and metabolic pathways using radio-HPLC and high-resolution, accurate mass LC-MS/MS
  • Comparative in vitro metabolism 
  • Enzyme phenotyping
  • CYP induction & inhibition

In Vitro Dermal Absorption (OECD #427 & 428) 

Also see PBPK Modeling (the Modeling & In Silico tab)

In Vivo Metabolism (OECD #417)

  • Pharmacokinetic, excretion balance, biliary excretion and tissue distribution phases using traditional necropsy methods or QWBA techniques


Toxicology (DART, Inhalation, Genetic)

Get market-leading toxicology capabilities for your safety assessment needs. Below is a quick overview of the toxicology studies, including inhalation and infusion routes of administration, available for your crop or chemical product testing needs. 

General, Genetic & Carcinogenicity Toxicology Studies

  • Ames test
  • Mouse lymphoma assay
  • Chromosome aberration test
  • In vivo micronucleus tests
  • In vivo unscheduled DNA synthesis test 
  • In vivo comet assay

OECD #s: 407, 409, 410, 411, 424, 4226, 451, 452, 453. 


  • Prenatal development toxicity
  • Reproduction / developmental toxicity screening
  • One-generation, two-generation and extended generation (EOGRTS) 
  • Endocrine toxicology (EPA standard in vivo panel)
  • Specialized endocrine function (pituitary, gonadal, adrenal, thyroid axis)
  • Extensive, proven behavioral testing
  • Fetal pathology including Wilson’s sectioning and microdissection techniques, staining for bone and cartilage
  • Computer-assisted sperm assessment (CASA)
  • Specialist pathology of male and female reproductive organs

OECD #s: 414, 415, 416, 421, 422 & 443. 

Inhalation Toxicology

  • Acute to two-generation reproductive studies
  • Cardiotoxicity to assessing anesthetic potential
  • Studies with specific approaches and dosing up to 24 hours/day
  • Online real time GC, IR and compound specific analyses with validated software
  • UPLC and HPLC analysis
  • Compound specific analysis
Ecotoxicology & Environmental Fate
Environmental Fate
  • Soil metabolism (aerobic, anaerobic and paddy)
  • Water/sediment metabolism (aerobic, anaerobic, irradiated)
  • Aerobic mineralization in surface water
  • Field soil dissipation, accumulation and leaching
  • Hydrolysis
  • Photodegradation in soil and water
  • Adsorption/desorption and column leaching
  • Environmental modelling
  • Metabolite identification

Terrestial Ecotoxicology

  • Earthworms
  • Bees
  • Non-target plants
  • Beneficial insects
  • Laboratory, extended laboratory, semi-field and field
  • Avian acute and subacute oral toxicity
  • Avian reproduction
  • Soil nitrogen and carbon transformation
  • Litterbag


Aquatic Toxicology
  • Acute
  • Chronic
  • Higher tier
  • Microcosms
  • Fish bioconcentration


  • Toxicity to sewage sludge
  • Ready and enhanced biodegradability
  • Inherent biodegradability
  • Anaerobic biodegradability
  • Marine biodegradation
  • Simulation tests

Field Trials

  • RAC trials
  • Processed commodity trials
  • Soil dissipation/accumulation studies
  • Dislodgeable foliar residue trials
  • Operator exposure
  • Field environmental fate
  • Field ecotoxicology

Environmental Metabolism

Environmental metabolism studies for the chemical industry are essential to maintain the safety of crops and livestock.  Your studies impact not only your product’s success in the market but also the future of the planet.

  • Metabolism studies in a wide range of crops outdoors, under polythene and in controlled-environment rooms
  • Metabolism and nature of the residue in goats, cows, pigs and hens (OECD #503)
  • Livestock feeding
  • Confined rotational crop metabolism
  • Processing - nature of the residue
  • Metabolite identification
  • Synthesis of isotopically labeled compounds and reference substances

Plant Metabolism (Crops & Rotational Crops)

  • Extensive range of plants and crops including
    • Cereals, pulses and oilseeds
    • Leafy crops, roots and tuber vegetables
    • Fruit crops
  • Capability for studies such as citrus, olive, apple and grape to be conducted via field co-operator in California, USA

Testing facilities include glasshouses, outdoor enclosures and growth rooms.

Product Chemistry & Bioanalysis

Residue Analytical Services

Residue analytical services include analysis of crop residues, processed commodities, environmental fate, ecotoxicology, livestock feeding and operator exposure studies.

  • Industry leading, multi-skilled scientific expertise with extensive experience of broad service offering
  • Method development, method transfer and method validation
  • Full range LC-MS/MS and GC-MS/MS instruments including Sciex API 6500
  • Dedicated sample preparation team using facilities fully equipped for high sample throughput
  • Independent laboratory validation
  • Mobile analytical support working on operator exposure studies

Product Chemistry

  • Chemical characterization including spectral analyses
  • Physical and chemical properties of chemicals
  • Analytical techniques such as HPLC (MS), GC (MS), UV, IR, ICP-MS
  • Active ingredient and formulation storage stability
  • Product certification for active ingredient content, including method validation
  • Batch analysis studies
Modeling & In Silico

Work with partners who understand the chemistry, toxicology and statistical basis behind models.

Through expert analysis, using the industry standard WinNonlin® platform as well as NONMEM®, PDxPop® and Gastroplus® platforms, you get more than just a data set, you get knowledgeable insights for better decision making. 

Our suite of (Q)SAR models consists of:

  • Biovia Discovery Studio (TOPKAT) 4.5 extensible
  • OECD Toolbox 3.3
  • DEREK Nexus 5.0.1
  • MultiCASE Ultra
  • VEGA NIC 1.1.1
  • US EPA T.E.S.T. 4.1
  • US EPA EPI Suite 4.11
  • ToxRead
  • ToxTree

REACH Consulting & Support

REACH requires all manufacturers and importers of chemicals into European markets to assess and manage the risks associated with their substances and products, and register them with the European Chemicals Agency (ECHA).

Given the long-term nature of the REACH database and the ongoing dossier and substance evaluation, any manufacturer or importer who has submitted a REACH dossier must keep that dossier up to date to ensure it:

  • Aligns with the latest regulatory legislation
  • Contains the most recent data
  • Includes new or extended uses for the substance
  • Reflects any changes to the tonnage in which it is used

Providing comprehensive REACH testing capabilities at our facilities located in England, Germany, and Spain, as well as regulatory offices in England, United States, Japan and Korea, we have been involved in more than 100 REACH registration dossiers that have been successfully submitted to ECHA.

  • Advice on registration and testing strategies
  • Registration of phase-in and non phase-in substances
  • Technical dossier preparation and submission in IUCLID 6
  • Joint dossier preparation
  • Exposure scenarios and chemical safety reports (CSR)
  • Full range of in-house, GLP-compliant testing services (Annex VII to X):
    • Analytical and physicochemical testing, toxicology, genetic toxicology, alternative testing, ecotoxicology and environmental fate
    • Only representative services on behalf of companies located outside of the European Union
    • Post-submission support
    • Consortium management
Endocrine Disruptor Screening Program (EDSP)

Endocrine Disruptor Screening Program (EDSP) In Vitro & In Vivo

The endocrine disruptor screening program is the US Environmental Protection Agency’s initiative for the screening of chemicals that may have the potential to cause endocrine disrupting effects such as those affecting the estrogen, androgen and thyroid hormone systems.

We can ally with you at all points in the EDSP process by answering your questions, helping you to arrive at a strategy, providing testing and giving you the regulatory support you may need.

Our screening program comprises of two tiers of testing:

  • Tier one: identifies the chemicals that have the potential to interact with the endocrine system.
  • Tier two: determines the endocrine-related effects and establishes the dose at which the effects occur.

Your endocrine disruptor screening program requires the employment of many disciplines:

  • DART 
  • Pharmacology
  • In vitro technologies
  • In vitro metabolism
  • Aquatic toxicology