Search

By Industry Solutions (2)
By Phase (1)
By Molecule Type (1)
By Therapeutic Area (3)
Covance Events (9)
Geography (3)
Keywords (10)

Filters

Showing results 1105 - 1120 of 91813 for .

Showing results 1105 - 1120 of 91813 for .

Comparison of Bile Acid Quantitation Using UPLC/HRAM MS in Full Scan and Targeted SIM Modes
ASMS 2016 -- Bile acids are produced in the liver by cytochrome P450-mediated oxidation of cholesterol. The increase of bile acid levels in human plasma can be used as a biomarker of hepatobiliary toxicity, aiding in the identification of harmful side effects of future therapeutics. Here we initially compared precision and accuracy using full scan mode versus tSIM at the LLOQ of four representative bile acids.
The Application of Highly Specific Reagents to Determine the Single Components of a Therapeutic Antibody Mixture in Both Clinical PK and Binding Activity Assays Using the Gyrolab™ Platform
European Bioanalysis Forum 2016 -- Highly specific reagents are crucial for the development of advanced bioassays in the field of therapeutic antibody mixtures due to the complexity of these drugs. Through collaboration between Symphogen and Covance, reagents have been produced and assays successfully developed on the Gyrolab™ platform.
Considerations for Clinical Pharmacokinetic Assays When Moving from Healthy Volunteers to Disease-State Populations
Gyrolab User Seminar 2015 -- Assessing multiple matrix factors when moving PK assays from normal healthy patients to disease-state.
The Application of Highly Specific Reagents to Determine the Single Components of a Therapeutic Antibody Mixture in Both Clinical PK and Binding Activity Assays Using the Gyrolab™ Platform
European Gyrolab Seminar 2016 -- Highly specific reagents are crucial for the development of advanced bioassays in the field of therapeutic antibody mixtures due to the complexity of these drugs. Through collaboration between Symphogen and Covance, reagents have been produced and assays successfully developed on the Gyrolab™ platform.
Improving the Accuracy of Peptide Retention Time Prediction by Machine Learning Techniques
ASMS 2014 - Liquid chromatography with tandem mass spectrometry (LC-MS/MS) is routinely used for protein identification (high resolution) and quantification (triple quadrupole). For protein identification, which is based on sequence database search using acquired MS/MS spectra of peptides, the theoretically calculated retention times of peptides can be used to filter peptides for improved protein identification...
High-Throughput Multiplexed SISCAPA® Assay for Targeted Protein Quantitation by LC-MS/MS
AAPS 2014 - SISCAPA® (Stable Isotope Standards and Capture by Anti-Peptide Antibodies) assays are a popular tool for validation of candidate protein biomarkers...
Degradation of Synthetic Peptides Caused by Thermal Denaturation during Targeted Proteomics Sample Preparation and Its Impact on LC-MS/MS Assay Accuracy
AAPS 2015 - In targeted proteomics, stable isotope-labeled synthetic peptides are often used as calibrators to build standard curves for the quantitative determination of endogenous target proteins in biological samples. This study compares the multiple reaction monitoring (MRM) results from different sample preparation protocols involving synthetic peptides introduced at different stages during the sample preparation process.
Quantitation of Oligonucleotides in Human Plasma Using Q-Exactive Orbitrap High Resolution MS
ASMS 2014 - Here we present high throughput generic LC-HR/AM (high resolution accurate mass) assay for the quantitative analysis of oligonucleotides and their metabolites in biological matrices using a Q-Exactive Orbitrap...
Progress in the Detection of Nitrogen-Rich Chemical Adulterants in Foods and Food Ingredients
AOAC INTERNATIONAL 2014 - Melamine and other nitrogen-rich food adulterants have caused global public attention. In this study, a high-throughput UHPLC-MS/MS method for simultaneous confirmation and quantification of melamine and related analogues (cyanuric acid, ammeline and ammelide) and dicyandiamide was developed and validated. The state-of-the-art UHPLC-MS/MS analysis offers the great combination of fast ESI+/ESI- switching, selectivity and sensitivity and speed for detection of these...
Veterinary Drug Analysis in Animal Origin Food and Feed and Their Relevant Products: A Modern Multi-Class, Multi-Residue Method Using UHPLC-MS/MS
EuroResidue VIII 2016 -- Veterinary drugs are a complex group of different chemical classes and therapeutic agents. They are used within animal husbandry to treat and prevent disease and ensure animal health and growth. Residues of such drugs in animal edible tissues are not desirable because they could pose a potential threat to consumer health and promote antibiotic resistant bacteria strains.
A High-Throughput and Sensitive Method for Quantitation and Identification of Chloramphenicol in Foods of Animal Origin Using UHPLC-MS/MS
North American Chemical Residue Workshop, NACRW 2015 - Chloramphenicol (CAP) is a broad-spectrum antibiotic and potential carcinogen that is banned by WHO and also banned in the United States, Canada, European and most Asian countries in food products. However, due to its broad activity and low cost, the illegal use still remains. In this study, a fast, high-throughput and sensitive UHPLC-MS/MS method for quantification and identification of CAP was developed and validated to determine...
Development and Optimization of a Multi-Class, Multi-Residue Method for Veterinary Drug Analysis in Infant Formula Ingredients and Products
Recent Advances in Food Analysis (RAFA) 2015, 7th International Symposium - A modern multi-class, multi-residue method for detection, identification and quantitation of veterinary drugs using liquid chromatography- tandem mass spectrometry (LC-MS/MS) is a highly effective approach for residue monitoring with the ultimate goal of protecting consumers from potentially unsafe exposure to drug residues in foods of animal origin (milk, meat, poultry, seafood, fish, egg and honey).