Search

By Industry Solutions (2)
By Phase (1)
By Molecule Type (1)
By Therapeutic Area (3)
Covance Events (9)
Geography (3)
Keywords (10)

Filters

Showing results 961 - 976 of 91813 for .

Showing results 961 - 976 of 91813 for .

Introducing a Novel Method for the Analysis of Vitamin D in Supplements Using Supercritical Fluid Extraction and Chromatography
Midwest AOAC 2017 -- The analysis of Vitamins D2 and D3 in nutritional supplements can be labor intensive and time consuming using traditional methods and instruments. As high-performance liquid chromatography (HPLC) systems are replaced with high-throughput, ultra high-performance liquid chromatography (UHPLC) systems, manual sample preparation and purification steps have become the bottleneck in the analytical process. With the recent introduction of the Shimadzu Nextera UC Supercritical...
The Use of Laboratory Automation in the Routine Analysis of EU Regulated Mycotoxins by UHPLC-MS/MS
World Mycotoxin Forum 2016 -- With the increased usage of ultra high performance liquid chromatography (UHPLC) coupled to tandem mass spectrometry, the analysis of mycotoxins has been greatly simplified and improved. Lower detection limits, reduction of false positives and confirmation of mycotoxin identity by mass spectral data are examples of the superiority of this technology compared to traditional means of detection.
Evaluation of Ion Mobility Enabled Collisional Cross Section Measurements for the Differentiation of Acyl and Phenolic Glucuronide Metabolites
ASMS 2016 -- Acyl glucuronidation is a common metabolic conjugation reaction of carboxylic acid drugs. Under physiological conditions, these reactive metabolites can isomerise by acyl migration, transferring the acyl group from the C-1 position of the glucuronic acid ring to the C-2, C-3 and C-4 positions, resulting in the formation of isomeric acyl glucuronides. They can also undergo spontaneous hydrolysis and nucleophilic substitution reactions with proteins. The formation of these...
Utilisation of Ion Mobility Enabled Collisional Cross Section Measurements for the Comparison of Metabolites across Differing Chromatographic Methods
DMDG 2016 -- During the conduct of metabolite profiling and identification studies, it is common to analyse samples using multiple chromatographic methods. As studies progress from in vitro to in vivo and clinical, it is often necessary to further develop chromatographic methods in order to separate and quantify additional metabolites. This experiment assesses the use of Ion Mobility Mass Spectrometry to differentiate between structural isomers of metabolites across UPLC and HPLC methods...
Evaluation of Ion Mobility Enabled Collisional Cross Section Measurements for the Differentiation of Acyl and Phenolic Glucuronide Metabolites
ISSZ 2016 -- Acyl glucuronidation is a common metabolic conjugation reaction of carboxylic acid drugs. Under physiological conditions, these reactive metabolites can isomerise by acyl migration, transferring the acyl group from the C-1 position of the glucuronic acid ring to the C-2, C-3 and C-4 positions, resulting in the formation of isomeric acyl glucuronides. They can also undergo spontaneous hydrolysis and nucleophilic substitution reactions with proteins. The formation of these...
An Evaluation of Cigarette Smoke Aerosols in Vitro Using a Modified Ames Methodology and the Balb/c 3t3 Neutral Red Uptake Cytotoxicity Assay
TSRC 2016 -- Cigarette smoke is a complex aerosol consisting of two fractions; the particulate phase constituting between 4-9% and the significantly larger vapour phase constituting the remaining >90%. Historically the tobacco industry has tested the particulate phase (TPM) by trapping the particulate matter on glass fibre pads and eluting it in dimethyl sulfoxide, and the vapour phase (GVP) by capturing the remaining vapour phase in a combination of matrices, prior to testing them...
Stabilization of Liposomal Formulations
AAPS 2014 - Liposomes are frequently used as a drug delivery system to enhance targeting, maintain specific drug concentration ratios, and reduce toxicity. Problems arise when attempting to measure the free portion of a liposomal formulation in a bioanalytical setting...
Meta-Analysis of Genomic Aberrations Identified in CTCs and ctDNA in Triple Negative Breast Cancer
AACR 2016 -- Technological innovation and scientific advances in understanding cancer at the molecular level have accelerated the discovery and development of both diagnostics and therapeutics. Circulating tumor cells (CTCs) and plasma circulating tumor DNA (ctDNA) are non-invasive prognostic markers that have been associated with metastatic and aggressive disease.
Longitudinal Analysis of Circulating Tumor Cells and Cell Free Tumor DNA by Next Generation Sequencing in Triple Negative Breast Cancer
SABCS 2015 - Scientific poster outlining Longitudinal Analysis of Circulating Tumor Cells and Cell Free Tumor DNA by Next Generation Sequencing in Triple Negative Breast Cancer
Metabolite Profiling of Oligonucleotides Using Liquid Chromatography Coupled with High-Resolution/ Accurate-Mass (HR/AM) Mass Spectrometry
AAPS-NBC 2017 -- For drug discovery through all stages, metabolite identification plays an important role. Recently, with advances of high-resolution mass spectrometry, analyzing drug-related information with the implementation of full-scan type analysis enables a much larger field of ions to be collected and analyzed per injection. The increased amount of detected ions over a set mass range has proven to be a significant tool for data mining, aiding in the identification of metabolites in...
Quantitative Analysis of Oligonucleotides Using Liquid Chromatography Coupled with High-Resolution/Accurate Mass (HR/AM) Mass Spectrometry
APA 2016 -- Oligonucleotide therapeutics have experienced tremendous growth in the past decade. However, one unexpected hurdle for such rapid growth has proven to be the development of sensitive and selective bioanalysis methods for such compounds. While the molecular basis for these therapeutics may be similar, the addition of modifications such as phosphorodiamidate, locked nucleic acids, gapmers, etc., may drastically change the physicochemical properties of these compounds. Here, we...
Quantitative Analysis of Oligonucleotides Using Liquid Chromatography Coupled with High-Resolution/Accurate Mass (HR/AM) Mass Spectrometry
ASMS 2016 -- Oligonucleotide therapeutics have experienced tremendous growth in the past decade. However, one unexpected hurdle for such rapid growth has proven to be the development of sensitive and selective bioanalysis methods for such compounds. While the molecular basis for these therapeutics may be similar, the addition of modifications such as phosphorodiamidate, locked nucleic acids, gapmers, etc., may drastically change the physicochemical properties of these compounds. Here, we...