Search

By Industry Solutions (2)
By Phase (1)
By Molecule Type (1)
By Therapeutic Area (3)
Covance Events (9)
Geography (3)
Keywords (10)

Filters

Showing results 929 - 944 of 91813 for .

Showing results 929 - 944 of 91813 for .

Quantitative Determination of Norepinephrine in Human Plasma by SPE and Derivatization followed by LC-MS/MS Analysis
AAPS 2014 - This work describes the validation of a sensitive method for the quantitation of endogenous concentrations of norepinephrine (also known as noradrenaline) in human plasma using UPLC-MS/MS...
Development and Validation of a Methodology for Analyzing Concentrations of MX-01 in Human Dried Blood Spot (DBS) Samples
AAPS 2014 - An accurate and precise methodology was developed and validated for quantifying the small molecule MX-01 in human dried blood spot (DBS)...
Investigation of Genetic Architecture of Multiple Myeloma by Next Generation Sequencing
AACR 2016 -- Myeloma is a genetically heterogeneous disease and is sub-classified based on the presence of structural variants and genetic mutations. Structural variants/copy number changes are historically identified by traditional methods such as karyotyping and fluorescence in situ hybridization (FISH). Although microarray based genome wide analyses greatly improve the resolution of structural variation, they may be limited by probe density.
Validation of the Meso Scale Discovery (MSD®) V-PLEX™ Cytokine Panel 1 (10-Plex) in Normal Human Serum (NHS)
AAPS - This work was designed to further validate the human Cytokine Panel 1 V-PLEX™ Plus biomarker assay system launched by Meso Scale Discovery (MSD®) using normal human serum (NHS) as sample matrix...
The development and validation of an ultra-sensitive double antigen ELISA method for the determination of etanercept (Enbrel®) in human serum
AAPS-NBC 2014 - Etanercept (Enbrel®) is a dimeric fusion protein. In this poster, we report on the development and validation of an ultra-sensitive method for the detection of Enbrel® that may be used to support clinical trials...
Microautoradiography Techniques: A Comparison of Frozen and Wax-Embedded Tissue Procedures and Outcomes
DMDG 2016 -- Covance Laboratories Ltd., has conducted micro-autoradiography (MARG) investigations to study the distribution of radioactivity at a cellular level for many years. Based on experience, MARG images of fixed and wax-embedded tissues seldom turn out to be comparable with regards to location and density of silver grains. Covance has recently conducted two investigations to determine if fixed and wax-embedded tissue samples are appropriate for use in MARG by processing and comparing...
Stratification of Metastatic Colorectal Cancer Patients Using DNA and RNA Sequencing
AACR 2016 -- Colorectal cancer (CRC) is the third most common type of cancer in the United States. Although chemotherapy, radiation and targeted therapies can improve survival rates, recent studies have shown the potential benefit of immunotherapies to improve outcomes for patients with advanced CRC.
Analysis of GSK525762 and its Major Oxidative Metabolites in Human Plasma Using Liquid Chromatography with Tandem Mass Spectrometric Detection
ASMS 2017 -- Bromodomains regulate epigenetically controlled processes through binding to acetylated histone tails. GSK525762 is a potent protein 4 (BRD4) inhibitor with an impact (via a bromodomain) on the proliferation and apoptosis of primary common B-cell acute lymphoblastic leukemia cells. Observed clinical toxicities and the presence of two oxidative metabolites of GSK525762 warrant the assessment of the metabolism of this molecule. Here we report an LC-MS method for analysis of...
Advances in Insulin Bioanalysis: A Strategy to Achieve 50 pg/mL in a High-Throughput LC-MS/MS Assay
AAPS-NBC 2015 -- LC-MS/MS solutions to the analysis of insulin analogs