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Showing results 897 - 912 of 91813 for .

Showing results 897 - 912 of 91813 for .

Stratification of Metastatic Colorectal Cancer Patients Using NGS Sequencing, Neo-Epitope Detection and Immune Infiltrate Analysis
AACR 2017 -- Colorectal cancer (CRC) is the third most common type of cancer in the United States. Although chemotherapy, radiation and targeted therapies can improve survival rates, recent studies have shown the potential benefit of immunotherapies to improve outcomes for patients with advanced CRC. Recently there have been major advances in detecting these chromosomal rearrangements. Fusion genes such as BCR-ABL and EML4-ALK have become targets for therapy in cancer. There is considerable...
Clinical Performance and Utilization of Three PD-L1 Immunohistochemical Assays
AACR 2017 -- PD-L1 expression has been an important biomarker used in the evaluation of patient samples for the consideration of treatment with checkpoint inhibitors. While other biomarkers such as mutational burden, genetic alterations resulting in neo-antigens, genomic instability, and blood based markers of immune function have also been investigated, PD-L1 expression continues to be a primary means of assessing for the potential patient response to treatment. Recently several assays...
Evaluation of the Heat Resistance of Salmonella enterica ser. Enteritidis PT30 on Honey/Syrup-Coated Almonds and Uncoated Almonds after Exposure to Hot Oil Treatment
IAFP 2016 -- The Almond Board of California (ABC) has conducted many years of research to study the efficacy of hot oil on the reduction of Salmonella enterica ser. Enteritidis PT30 on oil-roasted almonds. Based upon this research, a minimum process of 2.0 minutes of exposure to hot oil at 260°F or above is required to provide a 5-log reduction of S. enterica ser. Enteritidis PT30 on the surface of whole almonds. Since the studies to establish the oil-roasting pasteurization criteria for...
Development of a Highly Sensitive, Efficient, Combination Extraction Method for the Quantitation of Formoterol and Budesonide by UPLC-MS/MS
AAPS 2014 - Formoterol and budesonide are both used in the management and treatment of asthma and chronic obstructive pulmonary disease (COPD)...
The Bactericidal Effect of Wild Blueberries on Listeria monocytogenes
BHBS 2017 -- Listeria monocytogenes is a bacterial pathogen that has been associated with cases of foodborne illness linked to dairy, seafood, fruit, and vegetable products. This microorganism can be particularly problematic for the food industry due to its ubiquity in the environment, its ability to persist and grow at low temperatures, and the current U.S. 'zero tolerance' policy for ready-to-eat foods. Jasper Wyman & Son requested the assistance of The National Food Laboratory (now...
Progress toward the validation of liquid chromatography-tandem mass spectrometry-based methods for the quantitative determination of key kynurenine pathway metabolites in human plasma and ...
ASMS 2014 - Development and rigorous pre-validation testing of liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based methods for the analysis of five KP metabolites (kynurenine - KYN, kynurenic acid - KYNA, 3-hydroxykynurenine - 3OHKYN, anthranilic acid - AA, and quinolinic acid - QA) in both human plasma and cerebrospinal fluid (CSF)...
Using High Resolution Mass Spectrometry to Predict Successful Dosing Strategies for Radiolabelled Clinical AME Studies
ISSX-EU 2015 -- Early metabolite characterization to assess appropriate AME strategy to comply with regulatory guidance.
Long Term Performance Monitoring of Standardized Flow Cytometry Instruments by Covance Central Laboratory Services
ESCCA 2016 -- The recent focus of the pharmaceutical industry in immuno-oncology, auto-immunity, infection diseases and cell therapies, has led to an increase in the requirement of flow cytometry in support of all the drug development phases from fundamental research to late clinical development. Conducting flow cytometry in the context of longitudinal, and most-often multi-center, clinical trials in a regulated environment requires robust instrument-to-instrument standardization process in...
Development of a Robust GLP Bioanalytical Method for a Short-Lived Therapeutic Peptide
ASMS 2016 -- A heptapeptide therapeutic (DTI-100) is being developed for voluntary control of bladder functions to improve quality of life for patients with spinal cord injury or neurological issues. Peptides, which are known to degrade by both metabolic and chemical mechanisms, must be stabilized sufficiently for bioanalytical analysis. A series of experiments were undertaken to understand the stability issue of DTI-100 and find a means to stabilize the peptide, enabling accurate and...