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Showing results 33 - 48 of 399 for .

Showing results 33 - 48 of 399 for .

Source Your Rabbit Models with Confidence
Successful study outcomes require the right purpose-bred models. Whether you're conducting an ocular-related study or require a time-mated rabbit with high conception rates, you need a high quality model with consistent results.
Induction of Behavioural Sensitisation in CD-1 Mice: Cocaine and Morphine Dose Regimen Effects
SPS 2018 -- Drug-induced behavioural sensitisation results from an increase in sensitivity to potentially addictive drugs due to exposure-induced neural adaptations. These changes can last for many years, and may in part contribute to drug use disorders or relapse in susceptible individuals. Based on this principle, the ability of a novel test article to prevent sensitisation from occurring and/or to modify behavioural effects upon re-exposure to a drug may be indicative of its potential to...
A Data Analysis Strategy for Rodent Self-Administration Studies
SPS 2018 -- Self-administration of stimulants has been widely characterized in several animal species, and the corresponding data analysis is typically straightforward. However, for other drug classes, such as sedatives, a greater degree of variability between animals and test sessions exists, along with a relatively low self-administration response. As such, for drugs like midazolam and ketamine, standard statistical analysis is either too sensitive, or not sensitive enough to support...
Self-Administration of Diamorphine in Male Lister Hooded Rats
SPS 2018 -- Drug abuse liability assessment is required for drugs (parent or major metabolite) that penetrate the brain, regardless of the therapeutic indication. Self-administration is one of the nonclinical abuse liability assessment study types required by regulatory agencies and is typically performed using cocaine-trained animals. However, there are situations when an alternative training drug is required, for example an opioid. At Covance, opioid self-administration was characterised...
The Removal of Sedation for TB Testing
NC3Rs Primate Welfare 2018 -- After ongoing discussions with colleagues at several sites globally, we have been looking to globalize many different procedures. Through these collaborations, we have been able to share our knowledge, experience and expertise which have produced positive outcomes. One of these was the outcome of a review of the cost-benefit analysis of sedating nonhuman primate prior to Tuberculosis (TB) testing using the Tuberculin Skin Test method, which led to the decision...
Assessment of Relative Sensitivities of Crossover and Ascending-Dose Study Designs for Cardiovascular Telemetry Evaluation in Cynomolgus Monkeys
SPS 2018 -- ICH S7A-compliant core battery cardiovascular telemetry studies frequently employ crossover dosing designs, with single or double Latin square designs being especially popular. A common design in our facility for crossover studies is to perform dose administration once weekly, with the interim duration for cardiovascular data collection along a schedule appropriate for the expected test article pharmacokinetics/pharmacodynamics coupled with compound washout between doses. In...
Genotoxicity Assessment of Carboplatin Using the Pig-a Assay
UKEMS 2018 -- Carboplatin is a second generation platinum anticancer drug used in the treatment of various cancers including testicular, ovarian, lung, head and neck. Carboplatin has been tested as positive in a number of in vitro and in vivo genotoxicity tests, such as the Ames assay. The in vivo Pig-a gene mutation assay is based on the endogenous X-linked Pig-a gene. The Pig-a assay has been evaluated internationally and the data generated to date indicate that it is sensitive, robust...
Repeated Blood Sampling in Catheterised Rats: A 3R Approach Enabling Disconnection and Group Housing in an Infusion / Oral Cross-Over Study Design
LASA 2018 -- Pharmacokinetic studies are conducted during both discovery and development phases of a molecule, and provide rapid and robust data that are critical in decision making. Repeated blood sampling on up to 12 occasions within a 24-hour period is necessary in order to obtain a full understanding of pharmacokinetics (PK) of a compound. For a measure of absolute bioavailability, conducting this repeated blood sampling on the same animals within 72-96 hours would provide the most...
Genotoxicity Evaluation of Tobacco and Nicotine Delivery Products: Part 2. In Vitro Micronucleus Assay
UKEMS 2018 -- Next generation tobacco and nicotine tobacco products (NGPs) comprised of tobacco heating products (THP) and electronic nicotine delivery system (ENDS) have evolved significantly over the last few years and are gaining consumer acceptability. Available in vitro and in vivo clinical data indicate these products may possess significantly lower activity when compared to cigarette smoke, suggesting these products may be of reduced harm, when compared to cigarette smoking, and...
Determination of Pharmacokinetics of Acetaminophen and Assessment of Impact to Animal Health Following Multiple Serial Liver Biopsies in Cynomolgus Monkeys
AAPS PharmSci 360 2018 -- Laparoscopic serial liver biopsy sampling has been effectively used in preclinical large animal studies to obtain samples at designated times without requiring a terminal procedure or multiple major invasive surgeries. This sampling procedure reduces the number of animals required on a given study and allows for serial rather than sparse sampling design. The objectives of this study were to assess the impact of multiple laparoscopic liver biopsies on liver function...
Histological and Immunohistological Characterization of Idiopathic Chronic Colitis in Laboratory Nonhuman Primates
ESTP 2018 -- Idiopathic chronic colitis (ICC) is a common syndrome that is recognized in cynomolgus macaques used in preclinical toxicity studies. The syndrome is associated with diarrhea, weight loss and distension of the large intestine and histologically with epithelial hyperplasia, crypt atrophy, microabscesses, lymphoplasmacytic cellular infiltration and glandular microherniation. The syndrome is not always responsive to treatment and the etiological and contributory factors involved...
Your Sample Lifecycle
See how we enable efficiencies at every step of the process. From kit production to sample destruction, we'll show you how we create high-quality clinical trial sample data critical for your regulatory submission.
Consistent Sample Collection - Day in the Life Series
Follow along the journey of the sample as we show how robotics technology improves testing throughput and accuracy throughout our rigorous chain of specimen handling.
Why is a Central Lab Important - Day in the Life Series
Almost all clinical data for new drug development relies on a high-quality laboratory testing. Understand how consistency plays a key role in avoiding unnecessary delays and costs.
High Throughput Automated Testing - Day in the Life Series
Go Behind the Scenes in the Life of a Sample: See how we enable greater efficiencies - from data collection to delivery Clinical data for new drug development relies on high-quality laboratory testing. Take a fascinating behind-the-scenes look within our Covance Central Lab and see how specimens are collected, transported, stored and analyzed. From kit production to logistics, testing, sample storage and destruction, you'll see how our team delivers standardized, consistent, combinable...
Proactive Global Logistics - Day in the Life Series
Ensuring your specimens are received within stability is paramount to your trial's success. Learn how our team provides peace of mind and increases the reliability of your results, from specimen collection to receipt.