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Showing results 593 - 608 of 91813 for .

Showing results 593 - 608 of 91813 for .

Minipig and Human Metabolism of Aldehyde Oxidase Substrates: In Vitro-In Vivo Comparisons
DMDG 2016 -- Aldehyde oxidase (AO) is a cytosolic molybdoflavoprotein expressed in many tissues which significantly contributes to the metabolism of numerous drugs. The use of human liver microsomes (with no intrinsic AO activity) in in vitro clearance studies has led to marked underpredictions of human exposure to AO substrates, and species differences in the expression of AO may also lead to erroneous predictions of human exposure or the formation of potentially toxic metabolites when...
Characterization of Intra-Articular Dose Administration in the Stifle Joint of Rabbits for Toxicity Testing
ACT 2015 - Intra-articular administration is a standard therapeutic option for patients with rheumatoid arthritis, and pharmaceutical companies are increasing the research and development of injectable treatments. Therefore, there is an unmet need for reliable dosing models in toxicity safety testing. The rabbit stifle joint is attractive for toxicology testing of injectable treatments for rheumatoid arthritis because it is the largest synovial joint in the animal's body and is equivalent...
Histaminergic Reactions: Lower Susceptibility of Mice vs. Rats and Modification by the Infusion Rate
Society of Toxicology 2015 -- Feasibility of continuous infusion of freely moving mice via indwelling vein catheter was demonstrated, thereby avoiding dosing variability as seen with the traditional tail vein injection.
Group Housing of Dual Vascular Cannulated Rats for Intravenous/Oral Crossover Pharmacokinetic Studies - Welfare and Study Design Refinements
DMDG 2016 -- With the increased sensitivity of bioanalytical assays, it is possible to obtain concentration-time profiles from a single set of animals in a cross-over design, utilising both oral and intravenous dosing, rather than rely on the variability that exists when using separate cohorts of animals for each dose route. This is applicable to all species, including the rat. Intravenous/oral cross-over studies can be conducted using animals surgically prepared with jugular and femoral...
Evaluation of Serial Blood Sampling in the Minipig by Temporary Cannulation of the Saphenous Vein - Welfare and Study Design Refinements
DMDG 2016 -- The minipig is a viable non-rodent species for safety testing of novel test substances, which is becoming increasingly popular as an alternative to dogs or primates. Information on the pharmacokinetics of a test substance forms an important part of this testing to predict its efficacy and the duration of its effects, to provide supportive data on the mechanisms of drug action, to predict side-effects, and for the extrapolation of results from laboratory animals to man. A...
Evaluation of the Human TK6 Cell In Vitro Micronucleus Assay in the Presence and Absence of Cytochalasin B with Data Comparison of Three Model Compounds Using an Extended Treatment with and ...
GTA 2016 -- The in vitro micronucleus (MN) test has been applied widely in different cell types to assess cytogenetic abnormality. In our laboratory validation experiments, three reference genotoxicity compounds-Mitomycin C (MMC), a direct-acting clastogen; Noscapine (NOS), a direct-acting aneugen; and Cyclophosphamide (CP), a clastogen requiring metabolic activation-were tested in the in vitro MN assay in TK6 cells.
Enhancing Animal Welfare with Excel
How to use Excel to analyze data and help colony management. Presented at AALAS TriBranch 2016
European Veterinary Training Framework in Laboratory Animal Medicine
FELASA 2016 -- Informative presentation on how to develop a cohesive training approach from day-one competency to ECLAM Diplomate.