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Showing results 577 - 592 of 91813 for .

Showing results 577 - 592 of 91813 for .

Exacerbation of Seminiferous Tubule Dilatation by Fibrous Hypoplasia in Cynomolgus Monkey Testes
STP 2017 -- This poster provides comparative data on the incidence of tubular dilatation and fibrous hypoplasia in Asian monkeys and suggests that the presence of fibrous hypoplasia exacerbates the incidence and severity of tubular dilatation.
Options for Enhanced Analysis of Spermatogenesis in the Nonhuman Primate Model
ACT 2016 -- Evaluation of testicular functions is an important and compulsory aspect of preclinical safety assessment. Testicular toxicity is comparatively far more common than ovarian toxicity and histological evaluation of the testis is an integral part of regulatory toxicity studies. Testicular functions comprise the production and release of sperm and the production of androgens. This investigation focuses on options for the assessment of the spermatogenic function of the testis in the...
Integration of Safety Pharmacology Endpoints in Early MTD/DRF Studies
JSOT 2016 -- While previously the dose selection in early maximum tolerated (MTD) or dose range finding (DRF) studies was mainly based on findings in body weight, clinical observation, food consumption, clinical pathology, and feces evaluation, it can now also comprise evaluation of central nervous system (CNS), respiratory and cardiovascular safety assessment data. This poster suggests feasible study designs and discusses potential advantages and disadvantages considering different...
Extended Treatment with Recovery is Required for Detection of Certain Chemicals in the HPBL Micronucleus Assay
GTA 2016 -- The in vitro micronucleus (IVMN) test was endorsed for regulatory genotoxicity testing with the adoption of OECD test guideline (TG) 487 in 2010. In this study we measured average generation time (AGT) of human peripheral blood lymphocytes following phytohaemagglutinin (PHA) stimulation at various sample times up to 144 hours.
In Vitro Alternatives: Evaluation and Recommendations for the Reconstructed 3D Skin Micronucleus Assay (RSMN Assay): 72-Hour Protocol
GTA 2016 -- Skin is one of the 4 key routes of entry to the human body for xenobiotics. With an average surface area of approximately 1.5-2.0 m2 and complex multi-cellular composition, our skin is constantly exposed to many environmental as well as purposely applied chemicals (incl. pharmaceuticals and cosmetics). Protection comes from the continual renewal of this biological barrier as generated by the basal keratinocytes therefore assessment of damage to these cells by any purposely...