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Showing results 497 - 512 of 91813 for .

Showing results 497 - 512 of 91813 for .

September 2016 Rabbit Health Monitoring Status Report - Monthly
September 2016 Rabbit Health Monitoring Status Report - Monthly
Covance Research Products Research Models and Services
Covance Research Products Research Models and Services
Adrenal Gland Spontaneous Cortical Neoplastic Lesions and Phaeochromocytomas in a Control Syrian Hamster in a 2-Year Carcinogenicity Study: An Immunohistochemical Approach for Their Characterisation
EHF 2017 -- Distinction between primary cortical, phaeochromocytomas and metastatic tumours of the adrenal gland can be difficult because of confounding clinical presentations, overlapping morphologies and immunophenotypes that these tumours can present. Published background data reporting on the incidence of neoplastic lesions and studies conducted for the characterisation of these types of neoplasms in Syrian hamsters are still scarce and are somewhat limiting the correct interpretation...
Assessment of Electrocardiography (ECG) Parameter Variability when Building ECG Template Libraries
Safety Pharmacology Society 2015 - In order to characterize potential adverse cardiovascular effects in nonclinical safety studies, accurate quantitation of ECG data is critical to maximize statistical power, consistent with best practice recommendations. Preclinical ECG data collected using jacketed telemetry are routinely analyzed using pattern recognition software through the creation of template libraries of representative waveforms.
Assessment of Analyst Consistency in Marking Electrocardiograms (ECGs)
SPS 2016 -- Accurate and consistent marking of ECG waveforms is important for characterizing potential adverse cardiovascular effects in nonclinical safety studies. ECG analysis software typically has the capability of automatically marking ECG signals; however, trained human analysts are generally used to measure quantitative ECG intervals in short-duration recordings. In this study, we performed an Inter- and Intra-Operator Variability (IIOV) assessment to evaluate the consistency of mark...
Assessment of Electrocardiography (ECG) Parameter Variability when Building ECG Template Libraries from Implanted Telemetry Devices
SPS 2016 -- Accurate marking of ECG waveforms is important for the characterization of potential adverse cardiovascular effects in nonclinical safety studies and is critical to maximize statistical power, consistent with best practice recommendations (Leishman, et al., 2012). Preclinical ECG data collected using implanted telemetry are routinely analyzed using pattern recognition software using template libraries of representative waveforms. Changes in waveform morphology and imperfect...
Analytical Validation for Peripheral Blood Immunophenotyping of Myeloid, T and B Cell Populations in Cynomolgus Macaques
ACT 2016 -- The purpose of this study was to validate myeloid, T regulatory (Treg), T cell and B cell antibody panels for immunophenotyping evaluation of peripheral blood in cynomolgus macaques. The myeloid panel identifies plasmacytoid dendritic cells (pDCs) and myeloid dendritic cells (mDCs) and includes lineage markers (CD3, CD14, CD20) and DC markers (HLA-DR, CD123, BDCA-2, CD11c). The Treg panel includes T cell lineage markers (CD3, CD4, CD8) as well as activation markers (CD95, CD25)...
Validation of Drug Discrimination in the Lister Hooded Rat: Anti-Depressants
SPS 2016 -- In this study, the subjective effects of three different anti-depressants was characterised by determining if they had discriminative stimulus properties comparable to those of the tricyclic anti-depressant desipramine.