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Showing results 433 - 448 of 91813 for .

Showing results 433 - 448 of 91813 for .

Cardiovascular Data Analysis - How Much Do We Need?
SPS 2016 -- According to the ICH guidelines, Safety Pharmacology studies are required to investigate the time course of any effect (e.g. onset and duration). To accurately capture the time course of an effect it can be necessary to analyse data using a variety of different sized time bins dependent on the pharmacokinetic profile of the compound. An investigation was performed to determine how the size of the time bin impacts statistical sensitivity.
Impact of Social Housing on Time-Mated Rabbits in an Embryo-Fetal Development Study Design
ACT 2016 -- This poster looks at the impact of pair housing on the breeding of time mated rabbits and of pair housing pregnant females using sixty female NZW rabbits housed in a commercial production facility, randomized into a group of thirty single-housed rabbits and a group of thirty pair-housed rabbits.
Optimizing Animal Models for Non-Alcoholic Steatohepatitis: A NASH Case Study on Overcoming Preclinical Challenges
Optimizing NASH rodent models for NASH preclinical compound efficacy testing, resulting in compound progression to Phase II trials.
Diversity of Thymic Cysts in Cynomolgus Monkeys
STP 2017 -- This poster reports the results of a retrospective survey of thymic cysts performed on 130 purpose-bred Asian cynomolgus monkeys, 68 males and 62 females, from 16 safety assessment studies executed between 2015 and 2016. The incidence of thymic cysts was evaluated with respect to thymic involution, size, distribution, morphology and gonadal maturity.
Feasibility of Capillary Microsampling for Toxicokinetic Profile Analysis in the Juvenile Rat from Postnatal Day (PND) 4 Onwards
ACT 2016 -- Microsampling has received considerable interest in recent years by the pharmaceutical industry as this approach provides many scientific, ethical and also cost improvements over existing practices, e.g. lowering blood sample volumes, reducing animal numbers in every study and enabling utilization of less invasive blood collection procedures. In fact, this technique could be explored during many phases of the drug development process since current mass spectrometry enables...