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Showing results 289 - 304 of 91813 for .

Showing results 289 - 304 of 91813 for .

Application of Flow Cytometry: Scoring an In Vivo Bone Marrow Micronucleus Study in Under 1 Hour!
UKEMS 2016 -- In the 2014 revision to OECD Test Guideline 474 (in vivo micronucleus assay), the requirements for the number of immature (polychromatic, PCE) erythrocytes to be assessed for micronuclei (MN) was increased from 2000 to 4000 PCE. The impact of this change was an increase in both cost and time for MN analysis, which prompted us to consider flow cytometric methods for MN assessment in bone marrow.
Always Know Your Vehicle: Unexpected Nephrotoxicity and Pancreas Toxicity Induced by a Sulfuric Acid-Based Vehicle in Cynomolgus Monkeys (Macaca fascicularis)
ESTP Congress 2016 -- Numerous pharmaceuticals and an increasing number of monoclonal antibodies as well as antibiotics are undergoing regulatory preclinical trials in nonhuman primates by intravenous administration, often by continuous infusion for 24 hours or longer. When the drug is given as a solution or suspension, the vehicle must be selected carefully, to avoid confounding effects in the study, including adverse effects in animals. It is crucial to include vehicle controls in the...