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Showing results 209 - 224 of 91813 for .

Showing results 209 - 224 of 91813 for .

Genotoxicity Assessment of Procarbazine Using the Pig-a Assay
GTA 2016 -- Procarbazine [N-isopropyl-α-(2-methylhydrazino)-p-toluamide], a hydrazine derivative is used as an anticancer agent in the treatment of Hodgkin's disease and several other types of cancer. In the present study, we evaluated the genotoxic potential of Procarbazine in Sprague-Dawley rats using Pig-a and micronucleus (MN) assays.
Genotoxicity Assessment of Azoxymethane Using Micronucleus and the Pig-a Assay
GTA 2017 -- Azoxymethane (AOM) is an alkylating agent and a potent genotoxic carcinogen forming DNA adducts and initiating tumorigenesis. AOM-mediated carcinogenesis process involves genotoxicity by initiating chromosomal damage and induction of micronucleated cells. AOM cytotoxicity is considered to mediate oxidative stress. In the present study, we evaluated the genotoxic potential of AOM in Sprague-Dawley rats using Pig-a and MN assays. Two Pig-a mutation endpoints in erythrocytes,...
Antibody-Enhanced Intracellular Killing of Leishmania amazonensis Can Be Achieved by the Activation of Macrophages with Soluble Immune Complexes and Novel Recombinant Fc Constructs
STP 2016 -- Leishmania amazonensis are protozoal parasites that reside intracellular within macrophages and can cause cutaneous and visceral leishmaniasis. This disease is a vector borne disease that can affect approximately 1 million people each year. Our lab has shown that intracellular killing of L. amazonensis parasites requires a robust Th1 immune response with the production of NADPH oxidase generated superoxide from infected macrophages. These experiments define new mechanisms in...
Fact Book: Nonclinical Development Facts & Services 2017-2018
Scientists Helping Scientists -- Move your science forward - swiftly and confidently - to advance your best drug candidates with the greatest probability of success. We're here to help. Leverage us as your research partner and an extension of your team - take advantage of the deep scientific expertise and unique perspectives that have helped deliver more than a third of all the therapies on the market today. Assess drug safety, navigate regulatory hurdles and build a solid scientific...
Preliminary Tolerability of iPSC-Derived RPE on PLGA Scaffold Following Subretinal Implantation in RNU Nude Rats
ASGCT 2017 -- Dysfunction of retinal pigment epithelial cells (RPE) is an important factor in development of age related macular degeneration (AMD). RPE support photoreceptor function, and degeneration of RPE leads to retinal degeneration and vision loss. RPE replacement therapy has the potential to stop such degeneration. An implant composed of induced pluripotent stem cell (iPSC)-derived RPE cultured on a biocompatible poly-lactic-co-glycolic acid (PLGA) scaffold is currently under...