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Showing results 161 - 176 of 91813 for .

Showing results 161 - 176 of 91813 for .

Social Housing of Rats in Long-Term Studies: Effects on Food Consumption, Body Weight and Survival
Society of Toxicology 2015 -- The purpose of this study was to: - Compare food consumption, body weight and survival of social- or single-housed Sprague Dawley rats in two-year carcinogenicity studies - Compare results of Sprague Dawley rats with Wistar Han rats to determine which are more suitable for long-term studies
Surgical Animal Models in Support of 3Rs
Society of Toxicology 2015 -- Incorporating the principles of the 3Rs platform by maintaining an in-house colony of catheterized animals to reduce the overall number of animals, whilst still providing our clients a refined and proven surgical procedure, is of utmost importance.
Repeated Blood Sampling in Catheterised Rats: A 3R Approach Enabling Disconnection and Group Housing in an Infusion / Oral Cross-Over Study Design
SOT 2017 - Pharmacokinetic studies are conducted during both discovery and development phases of a molecule, and provide rapid and robust data that are critical in decision making. Repeated blood sampling on up to 12 occasions within a 24-hour period is necessary in order to obtain a full understanding of pharmacokinetics (PK) of a compound. For a measure of absolute bioavailability, conducting this repeated blood sampling on the same animals within 72-96 hours would provide the most robust...
Not a Small Molecule and Not a Biologic: Findings in Nonhuman Primate Studies with 2nd Generation Oligonucleotide-Based Therapeutics Targeting Neuronal Orphan Diseases
SOT 2017 - Within the last 2 decades, just a few oligonucleotides have received market approval by the FDA. However, preclinical development of oligonucleotide-based drugs has increased substantially over the past years. Many oligonucleotide drugs are developed for neuronal diseases and require direct administration into the cerebrospinal fluid (CSF). A thorough assessment of neurological function of the administration technique is required to fully differentiate test article-related...
A Sensitive Method for Measuring ECG and Haemodynamic Parameters
Society of Toxicology (SOT) 2016 -- Compound-mediated cardiovascular events are a major cause of attrition in drug development. The goal of the study was to evaluate the ability of the system to detect small changes in ECG and haemodynamic parameters after administration of the reference compounds sotalol, etilefrine and hydralazine.
Nude Female Mice Catheterised with the Pinport-in-Tail Cuff System, Allowing Disconnection of Tether (Potential Group Housing) in Intermittent Infusion Studies for Up to 108 Days
Society of Toxicology (SOT) 2016 -- Intravenous (i.v.) administration of test compounds in mice can be given as a slow bolus injection by the tail vein or by a surgically implanted catheter in the femoral vein with tail cuff exteriorisation.
3Rs Improvement: Are Satellite Groups for Toxicokinetic Evaluation of Control Groups Necessary?
SOT 2017 - This poster assesses the need for toxicokinetic evaluation of control rodents while following the 3Rs principles (replace, reduce, refine) for minimizing the number of animals used in each study.
Toxicokinetic Analysis of Acetaminophen following Liquid Microsampling - Evaluations of Rat and Mouse Plasma and Serum and Impact of Collection Site
Society of Toxicology (SOT) 2016 -- Interest in bioanalysis of dried blood spots has diminished somewhat due to substantial regulatory and technical challenges (e.g. effects of hematocrit on bioanalysis); therefore the use of small liquid samples (liquid microsampling) has been gaining popularity for nonclinical toxicokinetic (TK) analysis. The benefits of small sample volume collections are particularly striking in mouse studies including transgenic strains where reductions in the numbers...
Ocular Toxicity and Efficacy of rAAV2tYF-PR1.7-hCNGB3 Vector Following Subretinal Injection in a Mouse Model of Achromatopsia
Society of Toxicology 2015 -- Co-authored with OSOD -- The purpose of this study was to evaluate ocular tolerability and efficacy in rescuing cone phenotype of a recombinant adeno-associated viral (rAAV) vector expressing human CNGB3 (hCNGB3) under control of a PR1.7 cone-specific promoter (rAAV2tYF-PR1.7-hCNGB3) over 3 months.
Ocular Tolerability of rAAV2tYF-CB-hRS1 Vector Following Intravitreal Administration to Cynomolgus Monkeys
Society of Toxicology 2015 -- Co-authored with OSOD -- This non-GLP dose range-finding study evaluated ocular tolerability of an rAAV2tYF-CB-hRS1 vector delivered to cynomolgus monkeys via intravitreal injection.
Detection of Germ Cell Mutagens in the MutaMouse Transgenic Mutation Assay
Society of Toxicology 2015 -- The transgenic rodent mutation assay is a powerful tool in the Genetic Toxicology battery for investigating mutation effects in vivo in a wide range of tissues.
Cytokinesis-Block Micronucleus Assay Following Telomere and Centromere Staining
Society of Toxicology 2015 -- Following telomere and centromere staining, the aim of this study was: - Characterization of the cell focused on chromosomal instability, protein expression and telomere status - Distinguishing between clastogens and aneugens - Reevaluation of the sensitivity of CBMN assay - Scoring of induced chromosomal aberrations and quantification of telomere length
Telomere Instability in In Vitro Genotoxicity Assessment of Ethyl 4-Hydroxybenzoate
Society of Toxicology 2015 -- The effects of ethyl 4-hydroxybenzoate (antibacterial/antifungal agent used in cosmetic preparations) were evalutated in a battery of screening and Regulatory in vitro genotoxicity tests. The potential correlation of Ethyl 4-hydroxybenzoate (Ethyl Paraben) exposure in the presence and in the absence of metabolic activation (S-9), with the mutagenic effect and telomere dysfunction was also investigated.
Test for Learning Ability in Juvenile Cynomolgus Monkey Toxicity Studies
Society of Toxicology 2015 -- Learning ability is an important endpoint in juvenile chronic toxicity studies, especially if the examined drug targets the central nervous system. It has been shown that discrimination learning tasks are appropriate to study functional effects of neurotoxicant exposure (review: Burbacher and Grant, 2000). The double choice object discrimination task is an operant learning test, meaning the animals have to operate objects in their environment to obtain a reward...