Characterization of proliferation in multiple lymphocyte subsets in the CT26 murine colon carcinoma model by multi-color flow cytometry
David W Draper, Alden Wong, Dan Saims, Maryland Franklin, Matthew Thayer, and Scott Wise
AACR Annual Meeting
“Characterization of Proliferation in Multiple Lymphocyte Subsets in the CT26 Murine Colon Carcinoma Model by Multi-color Flow Cytometry”
Introduction and Background:
The efficacy of immune-modulating anti-cancer therapeutic antibodies that have been FDA-approved in recent years, such as anti-CTLA-4, anti-PD-1, and anti-PD-L1, has altered the paradigm of cancer treatment. Subsequently, the growing interest in the development of new single agent and combination therapies with immune-modulatory effects has generated a need for more powerful immunophenotyping techniques capable of in-depth cell characterization and proliferation assessment.