A comparative evaluation of immunotherapy responses in murine colon carcinoma

AUTHORS:

Sheri Barnes, Mary Anne Meade, Sumithra Urs, David Draper, Hillary Evens, Shayna Donoghue, Dan Saims, Scott Wise, Maryland Rosenfeld Franklin

 

YEAR:

 2018

 

AACR Annual Meeting

Introduction and Background

  • With the drive in oncology to develop molecules targeting the immune system, there is a need for reliable and well-characterized preclinical models.
  • The focus of immuno-oncology drug development has shifted to combination strategies with approved immunotherapies, immunometabolism targets, and costimulatory molecules.
  • To better understand the utility of these agents in preclinical development, we examined the response of CT26 to combinations with anti-mPD-1, a panel of costimulatory molecules, and epacadostat, an IDO inhibitor, using in vivo tumor growth delay studies.
  • Knowledge of immune composition and localization can help guide rational monotherapy and combination strategies. Investigation into these parameters are also contained in this body of work.