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Preclinical Oncology Resources
LL/2: An Immunosuppressive Murine Tumor Model
Lung cancer is the second most common cancer diagnosed in both men and women in the United States and is, by far, the most common cause of cancer-related deaths in men and women. In 2019, the American Cancer Society estimates that 228,150 new cases of lung cancer (116,440 in men and 111,710 in women) will . . . Read more about the LL/2 model
B16-F10: A Murine Melanoma Model
Skin cancers include carcinomas of all layers of the skin with the most common being basal cell (BCC) and squamous cell carcinomas (SCC). Melanoma and non-melanoma skin cancers (Merkel cell carcinoma, Kaposi sarcoma, cutaneous lymphoma and other sarcomas) are much less common. . . . Read more about a murine melanoma model
Preclinical Models of Multiple Myeloma
Multiple myeloma is a clonal B cell malignancy characterized by the accumulation of terminally differentiated, antibody-producing plasma cells in the bone marrow that is invasive and drug resistant. Patients are generally asymptomatic until very late state disease. There are few preclinical models that recapitulate human disease. In this work, we have evaluated the human MM.1S model and the murine 5TGM1 model . . . Read more about the preclinical models of multiple myeloma
In-Depth Myeloid Cell Characterization in the Murine Syngeneic CT.26 Colon Carcinoma Model by 10-Color Flow Cytometry
The efficacy of immune-modulating anti-cancer therapeutic antibodies that have been FDA-approved in recent years, such as anti-CTLA-4 and anti-PD-1, has driven growing interest in methods that provide a mechanistic understanding of drug function. . . Read more about In-Depth Myeloid Cell Characterization
About Preclinical Oncology
In 2019 Covance welcomed the preclinical pharmacology oncology provider, MI Bioresearch, into the Covance family. You can now access hundreds of cell line assays and tumor models, as well as thousands of potential oncology patients for clinical trials or explore an extensive library of oncology diagnostics.