Toxicology and Safety Assessment
Services: Genetic and Molecular Toxicology |
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| Genetic and molecular toxicology studies assess genetic damage caused by chemicals as well as the response to this damage. Covance provides a full range of in vitro, in vivo and exploratory screening genetic toxicology assays designed to meet established scientific standards and evolving regulatory mandates. Our team is supported by more than 90 full-time scientific staff in the USA and UK — with study directors each averaging 20+ years of experience in the field. And our state-of-the-art GLP study designs are in full compliance with OECD or ICH (PDF) guidelines. |
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| Genetic and Molecular Toxicology Assays |
| Assay |
In vitro |
In vivo |
Regulatory Assay |
Screening Assay |
| Ames test |
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| Gene mutation assay |
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- Mouse Lymphoma L5178Y cells, TK locus (agar or microtiter)
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- CHO / mouse lymphoma L5178Y cells, HGPRT locus
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| Chromosomal aberrations (human lymphocytes, CHO, and CHL) |
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| Micronucleus test |
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- CHO, V79, human lymphocytes, L5178Y mouse lymphoma cells
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- Rodent bone marrow or liver, peripheral blood
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| Comet assay |
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| SHE cell transformation assay |
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| Unscheduled DNA synthesis (UDS) test |
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| Non-disjunction (aneuploidy) testing using FISH or antikinetochore |
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| Photomutagenicity tests (Ames, chromosome aberrations in CHO cells) |
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| Cytotoxicity and phototoxicity assays |
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| Rodent bone marrow cytogenetics |
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| Transgenic rodent mutation assays (Muta™Mouse) |
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| Dominant lethal assay |
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| DNA binding/adducts |
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| Clinical trail and occupational cytogenetics monitoring |
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| EPISKIN™ assay |
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| EpiDerm™ assay |
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| GreenScreen assay |
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The Essentials of Genetic Toxicology
Julie Clements, PhD; David Kirkland, PhD; Tim Lawlor, MA; Leon F. Stankowski, Jr., PhD
Covance Evolutions Newsletter
Volume, 11, No. 3, January 2007
 Download PDF |
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