Screening Assays

When compounds and time are in short supply, genotoxicity screening studies conducted at Covance could be your answer.

Screening studies typically are abbreviated versions of regulatory-compliant assays and require far less test compound.  The following screening studies have been designed to efficiently screen many compounds at reduced cost and with shorter turn-around times, while allowing a reasonable ability to predict results in subsequent regulatory standard assays:

Hazard identification (in vitro)

  • Ames test
  • Gene mutation assay
    • Mouse lymphoma L5178Y cells, TK locus (agar or microtiter)
    • CHO / mouse lymphoma L5178Y cells, HGPRT locus
  • Chromosomal aberrations
    • Human lymphocytes, CHO, and CHL
  • Micronucleus assay
    • Human lymphocytes, TK6, CHO, V79, CHL, mouse lymphoma L5178Y cells
  • Comet assay
  • SHE cell transformation assay
  • Non-disjunction (aneuploidy) testing using FISH or antikinetochore
  • Photomutagenicity tests
    • Ames, chromosome aberrations in CHO cells
  • Cytotoxicity and phototoxicity assays

Hazard evaluation and risk assessment (in vivo)

  • Comet assay
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