|
When compounds and time are in short supply, genotoxicity screening studies conducted at Covance could be your answer.
Screening studies typically are abbreviated versions of regulatory-compliant assays and require far less test compound. The following screening studies have been designed to efficiently screen many compounds at reduced cost and with shorter turn-around times, while allowing a reasonable ability to predict results in subsequent regulatory standard assays:
Hazard identification (in vitro)
- Ames test
- Gene mutation assay
- Mouse lymphoma L5178Y cells, TK locus (agar or microtiter)
- CHO / mouse lymphoma L5178Y cells, HGPRT locus
- Chromosomal aberrations
- Human lymphocytes, CHO, and CHL
- Micronucleus assay
- Human lymphocytes, TK6, CHO, V79, CHL, mouse lymphoma L5178Y cells
- Comet assay
- SHE cell transformation assay
- Non-disjunction (aneuploidy) testing using FISH or antikinetochore
- Photomutagenicity tests
- Ames, chromosome aberrations in CHO cells
- Cytotoxicity and phototoxicity assays
Hazard evaluation and risk assessment (in vivo)
|
|
 |
|
|