Genetic and molecular toxicology studies assess genetic damage caused by chemicals as well as the response to this damage.  For over 30 years, Covance has worked with a wide range of industries, providing a full range of in vitro, in vivo and exploratory screening genetic toxicology assays, including multi-endpoint assays, designed to meet established scientific standards and evolving regulatory mandates.  Our team is supported by more than 90 full-time scientific staff in the USA and UK with study directors averaging 20+ years of experience in the field.  And our state-of-the-art GLP study designs are in full compliance with OECD or ICH guidelines. 

Our experience with non-standard assays can help you understand potential adverse issues that arise during the discovery or development phase.  These investigative assays provide a quick means to address issues with lead candidates later in the development cycle and help identify potential mutagenic impurities in material. 

Covance offers significant experience with the following methods:

  • Investigation of the origin of micronuclei (clastogenic or aneugenic)
  • Transgenic models
  • Comet assays
  • DNA binding studies
  • 28 day cytogenetic studies
  • Photomutagenicity
  • Cytogentic monitoring
  • In vitro toxicology
    • Cytotoxicity
    • Phototoxicity

Voice of the Scientist

View a presentation of a Covance scientist discussing Multi-Endpoint Assay.

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