Genetic and molecular toxicology studies assess genetic damage caused by chemicals as well as the response to this damage. For over 30 years, Covance has worked with a wide range of industries, providing a full range of in vitro, in vivo and exploratory screening genetic toxicology assays, including multi-endpoint assays, designed to meet established scientific standards and evolving regulatory mandates. Our team is supported by more than 90 full-time scientific staff in the USA and UK with study directors averaging 20+ years of experience in the field. And our state-of-the-art GLP study designs are in full compliance with OECD or ICH guidelines.
Our experience with non-standard assays can help you understand potential adverse issues that arise during the discovery or development phase. These investigative assays provide a quick means to address issues with lead candidates later in the development cycle and help identify potential mutagenic impurities in material.
Covance offers significant experience with the following methods:
- Investigation of the origin of micronuclei (clastogenic or aneugenic)
- Transgenic models
- Comet assays
- DNA binding studies
- 28 day cytogenetic studies
- Cytogentic monitoring
- In vitro toxicology