The complexities of the eye pose unique challenges in the design and conduct of ocular drug development studies.  Covance specializes in ocular studies in rodents and non-rodents, and is leading the way in supporting the nonclinical development of new ocular compounds.

In addition to our internal expertise, we have established an exclusive relationship with the specialists at the Ocular Services on Demand (OSOD), a consortium of internationally respected vision scientists.  The Covance/OSOD alliance creates a unique and superior resource for ocular drug development--one that will not only increase your confidence in the success of your study but enable you to keep timelines and costs firmly in line.  Ophthalmic studies conducted at Covance range from short-term investigative studies to chronic safety studies fully compliant with GLP standards.

Covance and OSOD offer the following ocular study capabilities:

  • Multiple routes of ocular dosing services
    • Intravitreal
    • Subretinal
    • Sub-Tenon's
    • Intracameral
    • Subconjunctival
  • Comprehensive clinical evaluations
    • Slit-lamp biomicroscopy
    • Indirect ophthalmoscopy
  • Quantitative inflammation evaluation with laser flare meter
  • Tonometry
  • Pneumatonometer
  • Application and rebound tonometers
  • Pachymetry
  • Specular photomicroscopy (contact and noncontact)
  • Ultrasonography
  • Fundus photography (film and digital)
  • Fluorescein angiography (film and digital)
  • Full-field and multifocal electroretinography (ERG)
  • Visual evoke potential (VEP)
  • Optical coherence tomography (OCT)
  • Iris colorimetry
  • Comprehensive ocular pathology
  • Pharmacology models
    • Laser-induced choroidal neovascularization (CNV)
    • Laser-induced ocular hypertention for glaucoma
    • Intraocular pressure measurements by telemetry
    • Glaucoma filtration model
  • Pharmacokinetic study capabilities (in vitro)
    • In vitro models of drug penetration across cornea and sclera
    • In vivo studies with labeled and unlabeled compound
    • Ocular tissues collected from anterior segment, posterior segment, and adnexa
    • Autoradiography of ocular tissues

Extensive collaboration with OSOD

  • Clinical comparative ophthalmology
  • Ocular pathology
  • Electrodiagnostics
  • Cornea/anterior segment
  • Ocular immunology
  • Fundus evaluation
  • Vitreoretinal surgery
  • Neuro protection
  • Ocular pharmacology
  • Ocular toxicology
  • Fundus photography reading center


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View a presentation of a Covance scientist discussing Species Selection for Ocular Studies.


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