As part of our safety pharmacology service offering, Covance offers a complete range of GLP-compliant ICH S7A (PDF) core battery tests to determine the potential undesirable pharmacodynamic effects of a compound on the cardiovascular, respiratory and central nervous systems, as well as supplementary tests to evaluate other organ systems.

The nonclinical evaluation of all human drug candidates for possible adverse effects on the function of the cardiovascular, central nervous and respiratory systems is required for compliance with the Internal Conference on Harmonization (ICH) Topic S7A and S7B guidelines.  Covance offers a complete range of GLP-compliant core battery tests including:

  • Cardiovascular system
    • chronically instrumented conscious canine and nonhuman primate models using radiotelemetry
  • Respiratory system
    • rodent whole body and head-out plethysmography
    • arterial blood gas in nonhuman primates
  • Central nervous system
    • modified Irwin test in rodents and nonhuman primates
    • automated behavioral assessment in nonhuman primates
  • Combination cardiovascular/respiratory
    • anesthetized canine and nonhuman primate models
  • hERG assay