Turnkey Vaccine & Anti-infective Development Services

Unmet needs from around the globe are driving the demand for more robust, efficacious and useful vaccines and anti-infectives.  In close collaboration with our clients, Covance scientists are bridging knowledge gaps, fostering scientific progress and driving development decisions by providing turnkey solutions for vaccine and anti-infective development.

Vaccine & Anti-infective Services

Covance delivers a comprehensive suite of immunogenicity, proof-of-concept and efficacy services for vaccine and anti-infective discovery, development, and testing and is pleased to announce the availability of expanded challenge and efficacy models including:

• Validated stocks of well-characterized infectious challenge agents for evaluating prophylactic and therapeutic vaccines and anti-infectives
  • Bacterial challenge strains:

  Organism: Staphylococcus aureus Model: Kidney Abscess Model Study type: Challenge Model / Efficacy Model Endpoints: Clinical Symptoms / Bacterial Load

  Organism: Clostridium difficile Model: Hamster Oral Gavage Model Study type: Challenge Model / Efficacy Model Endpoints: Clinical Symptoms / Bacterial Load / Histopathology

  • Viral challenge strains:

  Virus: Influenza Model: Ferret Study type: Challenge Model / Efficacy Model Study duration: Varies Endpoints: Clinical Symptoms / Viral Load

  Virus: RSV Model: Cotton Rat Study type: Challenge Model / Efficacy Model Study duration: Varies Endpoints: Clinical Symptoms / Viral Load

  • Herpes simplex virus (HSV) - coming soon
  • Custom model development

Other services available

• Quantitative immune response assessments and analyses of in-life and post-life samples
• Extensive Covance Discovery capabilities to analyze immunity in response to a variety of antigen systems and to elucidate the mechanism of action of various adjuvants:
  • Identification of cytokine profile(s) involved  in the elicitation of an immune response
  • Determination of whether  TH1 or TH2 pathway is utilized
    • Cytokine analysis and profiling can be carried out employing a wide array of assay platforms including flow cytometry, ELISA, MSD and Luminex
  • Analysis of immune modulation driven by a specific adjuvant or a cytokine
  • Evaluation of immune recognition using cell-based assays at the Covance Biomarker Center of Excellence

These services, in conjunction with the services Covance offers for existing preclinical vaccine testing, provide complete, turnkey product development solutions for your vaccine and infectious disease programs.

Why Covance? 

Solving complex studies are a Covance specialty, including projects that require extensive scientific consultation/interpretation, protocol development, or studies requiring collaborative input from diverse combinations of our immunology, vaccinology, genomics, in-vivo pharmacology and biomarker capabilities. Support your research and drug development needs by leveraging our expertise, extensive resources, and successful product development strategies with our:

• Rapid study start-ups
  • Time is measured in days rather than weeks – studies start days after the protocol is finalized as per regulatory requirements.
• Scientific expertise
• Large-scale operations
• Diversity of animal species
• High capacity

Accredited Facilities

Covance maintains significant capacity for large numbers of studies in BSL-1 and BSL-2 containment facilities, which are AAALAC-accredited and USDA-registered.

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