The protocols shown below are the standard protocols that we offer. Dosages, injection routes and timing can be adjusted as needed. We can also accommodate client-supplied custom protocols upon request.

It is highly recommended that your lab monitors the titer of antigen specific antibody throughout the study or that Covance performs ELISA screening on any pre-bleed, test bleed, production bleed or terminal bleed as proactive steps can be taken throughout the study to increase response to the antigen.

Sample Protocols using Protein Immunogens
Animal Antigen Required Estimated Serum Volume*
Rabbit Protein, 59 Day [Accelerated Protocol] 500 ug 70 mL
Rabbit Protein, 77 Day 625 ug 110 mL
Rabbit Protein, 84 Day 750 ug 95 mL
Rabbit Protein, 118 Day — Standard Historically Successful 875 ug 120 mL
Guinea Pig Protein, 115 Day 700 ug 19 mL
Rat Protein, 118 Day 600 ug 15.5 mL
Mouse Protein, 118 Day 400 ug 0.8 mL
Goat / Sheep Protein, 118 Day 2.5 mg 1000 mL
Chicken Protein, 118 Day 875 ug 18 mL**

** Eggs yield 40-100 mg IgY per egg, ~5-7 eggs per week


Sample Protocols using Peptide Immunogens
Animal Antigen Required Estimated Serum Volume*
Rabbit Peptide, 59 Day [Accelerated Protocol] 1.0 mg 70 mL
Rabbit Peptide, 77 Day 2.0 mg 90 mL
Rabbit Peptide, 84 Day 1.75 mg 95 mL
Rabbit Peptide, 118 Day — Standard Historically Successful 2.0 mg 115 mL
Guinea Pig Peptide, 115 Day 1.5 mg 19 mL
Rat Peptide, 118 Day 1.5 mg 15.5 mL
Mouse Peptide, 118 Day 0.8 mg 0.8 mL
Goat / Sheep Peptide, 118 Day 7.0 mg 1000 mL
Chicken Peptide, 118 Day 2.0 mg 18 mL**

** Eggs yield 40-100 mg IgY per egg, ~5-7 eggs per week