Meet all your development needs with the wide range of animal health preclinical vaccine services from Covance:

• Immunogenicity testing on formulated vaccine
• Dose stability
  • thermostability, real time, accelerated and reconstitution stability
• Dose response studies
• Efficacy testing
  • vaccination and serology
  • infectious agent challenge (up to ABSL-2)
• Development of potency testing for vaccine release
  • guinea pig potency
  • mouse potency
• Safety studies - veterinary vaccines only
  • master seed safety - modified live vaccine agents
    • 10X dose
    • reversion to virulence
    • non-target species safety
  • master cell stock safety - gross pathology in target species
    • oncogenicity
    • tumorigenicity
  • vaccine safety - modified live, killed and recombinant subunit
    • single and repeat dose toxicity
    • overdose toxicity
      • 10 doses for modified live
      • 2 doses for killed
  • qualification and validation studies - batch/lot release studies
  • equivalency testing
  • lot to lot comparison
  • lots from different manufacturing sites
• Field safety studies
  • 3 geographic locations
  • 100-200 animals/study, 20% targeted age
• Safety and immunogenicity