Trust in over 30 years of Covance experience with in vivo absorption, distribution, metabolism and excretion (ADME) studies as part of the critical safety assessment of your drug candidate. Access unrivaled expertise and capacity for designing and conducting in vivo radiolabeled ADME studies, including:

• Studies with different isotopes:
  • ¹⁴C, ³H, ¹²⁵I, ³⁵S, ¹¹⁹Sn
• A variety of species:
  • mouse, rat, hamster, ferret, rabbit, dog, primate, minipig
• Excretion and mass balance
• Placental and lacteal transfer in murine species
• Quantitative whole-body autoradiography (QWBA) distribution and excision
• Specialized routes of administration:
  • intravenous infusion
  • dermal
  • ocular
  • intravitreal
  • sub-tenon
  • inhalation
  • intravesicular
• Dosimetry calculations for human radiolabeled studies
• ADME support for agrochemical and animal health product development
  • Livestock
  • avian species