Drug Metabolism & Pharmacokinetics
In vivo Radiolabeled ADME

Trust in over 30 years of Covance experience with in vivo absorption, distribution, metabolism and excretion (ADME) studies as part of the critical safety assessment of your drug candidate. Access unrivaled expertise and capacity for designing and conducting in vivo radiolabeled ADME studies, including:

  • Studies with different isotopes:
    • 14C, 3H, 125I, 35S, 119Sn
  • A variety of species:
    • mouse, rat, hamster, ferret, rabbit, dog, primate, minipig
  • Excretion and mass balance
  • Placental and lacteal transfer in murine species
  • Quantitative whole-body autoradiography (QWBA) distribution and excision
  • Specialized routes of administration:
  • Dosimetry calculations for human radiolabeled studies
  • ADME support for agrochemical and animal health product development
    • Livestock
    • avian species
Voice of the Scientist
View a presentation of a Covance scientist discussing Tissue Distribution Studies Using Whole-Body Autoradiography.
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