Gain early insights into the metabolism of your drug candidate while minimizing the use of animals with Covance in vitro metabolism studies. Covance routinely performs in vitro assays, including:

  • CYP450 induction in fresh human hepatocytes (in vitro) and rodent, dog and primate liver (ex vivo)
  • In vitro CYP450 inhibition (IC50 and Ki)
  • Identification of specific CYP450 enzymes involved in the metabolism of the test article
  • Species comparisons of in vitro metabolism in microsomes and hepatocytes
  • Metabolite identification & profiling, including: accurate mass measurement

Case Study

Download a case study on How a Covance in vitro Discovery Reduced the Risk of DDI for a Phase II Trial.