Metabolic Stability, Cyp Induction, Inhibition & Reaction Phenotyping
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Gain early insights into the metabolism of your drug candidate while minimizing the use of animals with Covance in vitro metabolism studies. Covance routinely performs in vitro assays, including:
- CYP450 induction in fresh human hepatocytes (in vitro) and rodent, dog and primate liver (ex vivo)
- In vitro CYP450 inhibition (IC50 and Ki)
- Identification of specific CYP450 enzymes involved in the metabolism of the test article
- Species comparisons of in vitro metabolism in microsomes and hepatocytes
- Metabolite identification & profiling, including: accurate mass measurement
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Case Study
Download a case study on How a Covance in vitro Discovery Reduced the Risk of DDI for a Phase II Trial.
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