Determine oral membrane permeability with Caco-2 in vitro absorption studies from Covance. Caco-2 cell monolayers are an excellent model for oral permeability and the investigation of absorption mechanisms involving P-gp and BCRP. Let Covance determine:
Apical to basolateral transport as a model for physiological absorption from the lumen
Basolateral to apical transport as a model for exsorption and determination of efflux ratios
Rank order of the absorption potential of your compounds
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