Capitalize on the intricacies of research questions honed over thousands and thousands of in vivo pharmacology studies conducted by Covance. Our In Vivo Pharmacology (IVP) facilitates early discovery decisions by addressing questions related to:

• Assessing and engaging the target tissues (Exposure/Receptor Occupancy)
• Modulating target activity (Pharmacodynamic/ disease markers)
• Pharmacological efficacy  
• Selective engagement of target (Selectivity)
• Comparisons to reference compounds and structural analogs (Optimization)
• Side effects/adverse effects

Procure Covance's in vivo pharmacology expertise and capabilities for your benefit in the design, validation, conduct, and analysis of animal efficacy pharmacology studies for your drug candidates.

Therapeutic expertise includes rodent and non-rodent disease models for:

• Cardiovascular
• Inflammatory diseases
• Infectious disease
• Metabolic diseases (diabetes, obesity and atherosclerosis)
• Musculoskeletal diseases (osteoporosis, osteoarthritis)
• Neuroscience (behavioral and neurochemical assays)
• Oncology (xenograft , syngeneic, heterotopic and orthotopic models)
• Renal diseases
• PK/PD models (e.g., oncology target inhibition)
• Receptor occupancy (tracer discovery and assay implementation)
• Customized efficacy screening assays
• Model development expertise (pharmacology, surgery, imaging)
• Project consultation